Can a zygote have chromosomes from multiple people? (3+)

[later2pharm]

---

Members do not see this ad.

This is what Im trying to ask. In a human zygote, Lets say the egg is composed of chromosomes from 3 different females. chromosomes 1-10 from female A, 11-17 from female B and 18-23 from female C. And a simliar contribution in the sperm cell from three males, A B and C. So in effect this zygote would become a child with 6 parents. Is this possible right now? If so, what is the term used to describe this?

 

[CoolWhipp]

This is what Im trying to ask. In a human zygote, Lets say the egg is composed of chromosomes from 3 different females. chromosomes 1-10 from female A, 11-17 from female B and 18-23 from female C. And a simliar contribution in the sperm cell from three males, A B and C. So in effect this zygote would become a child with 6 parents. Is this possible right now? If so, what is the term used to describe this?

I believe you can do this.

 

[vman51]

This is what Im trying to ask. In a human zygote, Lets say the egg is composed of chromosomes from 3 different females. chromosomes 1-10 from female A, 11-17 from female B and 18-23 from female C. And a simliar contribution in the sperm cell from three males, A B and C. So in effect this zygote would become a child with 6 parents. Is this possible right now? If so, what is the term used to describe this?

well, unless those females are from earlier generations (ie grandmother gave her child chromosomes 18-23, then that F1 child gave her daughter 11-17 and her mother's 18-23, and F2 gave those and her own 1-10..all this is statistically extremely unlikely, just to throw out there)

maybe its possible in a lab, even then, I dont know of a technique that allows this..

otherwise, I'm not sure how you can get that, but someone please correct if i'm wrong..

 

[MexicanDr]

well, unless those females are from earlier generations ..

I would say this is the only way possible in a natural way..

 

[CoolWhipp]

You can do this, I'm almost positive. Have you guys heard of dolly the sheep? It would involve a similar process. You extract the chromosomes while they are condensed in mitosis, you karyotype them and do as you said- pick the chromosomes you are interested in. You then insert the chromosomes into a female egg that is denucleated and you use hormones and an emulated calcium flux.

Now that I think about it, you might have to artificially add some nuclear membrane proteins and there associated enzymes as well. Meh, my plan may not work. But, I'm confident that you could do what you said above.

 

[armybound]

blighted ovum

it can happen, but it won't survive

or do you mean still the normal 46 chromosomes?

 

[Parts Unknown]

So in effect this zygote would become a child with 6 parents. Is this possible right now? If so, what is the term used to describe this?

One helluva Saturday night.

 

[KeyzerSoze]

No, this is not currently possible. It's totally different from Dolly, btw.

 

[whoknows2012]

cloning, as was the case with dolly, involves denucleating an egg and inserting somatic nuclear material, it does not involve selectively placing in certain chromosomes and I agree that I don't think this is possible right now

 

[redsquareblack]

You guys are forgetting a possibility...

If either parent is a tetragametic chimera, then his or her child could conceivably (no pun intended) have chromosomes from at least three separate genomes.

 

[CoolWhipp]

I know what SCNT is. I merely mentioned dolly as an example of gene transfer for people who haven't taken general biology courses like MexicanDr.

 

[CoolWhipp]

You guys are forgetting a possibility...

If either parent is a tetragametic chimera, then his or her child could conceivably (no pun intended) have chromosomes from at least three separate genomes.

LOL! I remember reading a paper on a mother of 3 children, 2 of them which had a discrepancy between DNA tests. It took scientists awhile to figure out that she was chimeric. A miracle of anatomy that she doesn't need immunosuppressants.

 

[later2pharm]

blighted ovum

it can happen, but it won't survive

or do you mean still the normal 46 chromosomes?

yeah still 46 total. and artificial of course as taht would never happen naturally .

 

[schrizto]

I had a friend who told me she thought she was a chimera, lol.

 

[mmmcdowe]

I haven't heard of anyone doing this in animals, and I imagine that there would be some difficulties in getting the male or femal chromosomes all to aggregate into one egg/sperm, but it wouldn't surprise me if it was doable.

 

[MedicalVballer]

One helluva Saturday night.

LOLL 👍

 

[schrizto]

One helluva Saturday night.

Lol, didn't see that earlier.