Can anyone do this???

[htyotispharm]

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A drug should be infused at 185 mg/h to maintain a steady-state plasma concentration of 500 mg/L. If 250 ml of an IV solution contains 2.75 g of drug, at what flow rate (in ml/min) should the solution be administered to maintain a Css of 500 mg/L?


It looks easy but I am stumped. Any help is greatly appreciated.

 

[VCU07]

I am not sure if i did this right either but, here:

the rate should be 0.28ml/min

2.75g/250ml = .185g/Xml this comes out to 16.8ml/hr
/60=0.28ml/min

 

[MountainPharmD]

Here is another one come on guys only one answer....

 

[Epic]

0.28ml/min is correct.

And it is easy.

 

[Aznfarmerboi]

Of course it is easy, it is a one compartment kinetic model. . . . i mean come on =O. Does it get any easier??? Maybe the poster didnt read the question more carefully?

 

[pharaway]

Here's the solution using dimensional analysis approach:

185 mg/h x 1g/1000mg x 250 ml/2.75g x 1h/60 min = 0.28 ml/min

Starting with the desired dose or rate usually will get you on the right track.