Can HDL be too High

[USMELL]

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Okay my mom just got her lab results back, and her LDL was 98, TG 47 and HDL over 100. Obviously I know over 50 in a woman is good, and LDL less than a 100 is good. But why is her HDL so high, can that be bad, because her total cholesterol is now considered high? Also what can raise one's HDL to that level.

I searched online, and can't get any info, any help would be appreciated.

 

[BaylorMed2011]

Hey, I think that your mom's very high hdl levels may be a good thing. To assess heart disease risk, you divide total cholesterol by the hdl level. I'm not an expert though. Here are some websites:

http://patients.uptodate.com/topic.asp?file=hrt_dis/7390
http://studenthealth.oregonstate.edu/answerspot/message.php?message=6196

 

[DoctorFunk]

I bet her physician might have an idea. You should ask them.

 

[indo]

defibrillate!

 

[78222]

When in doubt, cut it out!!!!!!

 

[Scottish Chap]

Okay my mom just got her lab results back, and her LDL was 98, TG 47 and HDL over 100. Obviously I know over 50 in a woman is good, and LDL less than a 100 is good. But why is her HDL so high, can that be bad, because her total cholesterol is now considered high? Also what can raise one's HDL to that level.

I searched online, and can't get any info, any help would be appreciated.

No, it's totally fine. She probably has one of the well-documented CETP gene polymorphisms that prevents HDL metabolism in the blood. It's common in Greek populations, and it's atheroprotective.

 

[USMELL]

????

 

[USMELL]

No, it's totally fine. She probably has one of the well-documented CETP gene polymorphisms that prevents HDL metabolism in the blood. It's common in Greek populations, and it's atheroprotective.

I doubt we have any greek heritage though?

 

[Law2Doc]

No, it's totally fine. She probably has one of the well-documented CETP gene polymorphisms that prevents HDL metabolism in the blood. It's common in Greek populations, and it's atheroprotective.

There are high HDL mutations in peoples other than greeks too. I agree it's a generally a good predisposition, not a bad one.
Tell her she can eat lots of eggs and butter without worrying as much as the rest of us.🙂

 

[dsherida]

From what I understood from biochem. having an HDL over 60 allows you to subtract a risk factor for heart disease...ie. this is a great thing!

 

[Nflow]

.

 

[liverotcod]

Seriously, folks with really high HDL don't die. At least of anything related to atherosclerosis. I suppose they do eventually die of something.

 

[Baps]

A high HDL is not a bad thing. In fact, there really is no limit in terms of how high HDL should be. Drinking red wine for example in moderation is raises HDL levels (good cholesterol). What you should worry about is LDL (bad cholesterol). If you have a relatively high LDL (say 240) but your HDL is about 80 then there shouldn't be much concern. As someome stated earlier, you want to look at the ratio of HDL to LDL. Hope this helps a bit.

 

[indo]

CAN HDL BE TOO HIGH?

Q. Is a significantly elevated HDL (90-100 mg/dL) reason for concern?


A. In general, high levels of HDL are associated with decreased cardiovascular risk. However, the different constituents of HDL have qualitative effects on its function and metabolism, and the composition of HDL particle size relates to its anti-atherosclerotic properties. Therefore, the same HDL level has varying protectiveness, depending on its actual composition. A genetic deficiency in cholesterol ester transfer protein (CETP) is associated with marked increases in HDL levels in homozygotes and with moderate increases in heterozygotes. A Danish study that evaluated the effect of this mutation on lipids and risk of ischemic heart disease (IHD) found that although this mutation was associated with elevated HDL, it was also associated with increased IHD in white women (Circulation. 2000;101:1907-1912).




Question Raiser: K. VanWagner, MD
Date answered: 10/06/06
Disease categories: Cardiovascular disease, Coronary artery disease
Areas of Interest: Cholesterol, Heart disease
Medical Specialties: Family Medicine, Internal Medicine, Cardiology
Consultant: Norma M. Keller, MD
In Print: No





website:
http://www.cortlandtforum.com/conte...rs_pi1[mode]=1&tx_gotanswers_pi1[showUid]=286

 

[indo]

If HDL becomes too dense it is sticky and problematic. Consult your local biochem notes.

 

[indo]

It's not lupus.

 

[MadameLULU]

It's not lupus.

lol

 

[Law2Doc]

A genetic deficiency in cholesterol ester transfer protein (CETP) is associated with marked increases in HDL levels in homozygotes and with moderate increases in heterozygotes. A Danish study that evaluated the effect of this mutation on lipids and risk of ischemic heart disease (IHD) found that although this mutation was associated with elevated HDL, it was also associated with increased IHD in white women (Circulation. 2000;101:1907-1912).

Interesting, but I'm fairly sure there is more current research out there that suggests more benefits than negatives of high HDL levels.

 

[Scottish Chap]

Interesting, but I'm fairly sure there is more current research out there that suggests more benefits than negatives of high HDL levels.

You are correct. Also, the kind of HDL might also be important in the odd person (HDL-3, HDL-2 etc.). I was an HDL researcher in my last career. USMELL: you can use PUBMED yourself to find those studies.

 

[aphistis]

SDN isn't for giving medical advice. Please consult your physician.