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Your post was very difficult to understand, but I think you were trying to ask if you can apply with two science letters, a non-academic letter, and one DO letter. The short answer is yes; however, some schools such as PCOM require a letter from a pre-professional adviser.
What are COM that require U have to submit pre prof adviser letter? Can u list them if you don't mind 🙂
Just the PCOMs if I am correct.
It's not required by all schools - but I'd check with each school website and if it's not there, call.