I want to open a discussion about a case I feel one of the challenging ones I've seen.
81 year old patient came 2 days ago to the ER with renal colic and a hydronephrosis on the right side and urosepsis was diagnosed. Pre-existing ilnesses: chr. renal failure stage 4, chr. heart failure NYHA 2, multiple heart valve insufficiency.
Antibiotics (Cefuroxim) was started after taking blood cultures which showed presence of E.coli.
Yesterday morning noradrenaline per pump with a rate of 0.5 μg/kg/min and a lactate of 7. PCT 70 and CRP 200. Then an emergency operation to relieve the obstruction on the right side, where pus was seen flowing out of the obstructed ureter.
Postoperative the patient was tachypnic, instable with a heart rate of 150/min. Due to bed issues in our critical care the patient was transferred to the intermediate care, where she had a CPAP mask and 0.7 μg/kg/min noradrenaline. Fluids were running on the rate of 200 ml/h. After noticing that urine output was nearly 0, 40 mg Lasix were administered, which didn't bring any benefit. Then 500 ml fluids over 20 min. were administered which afterwards the heart rate reduced to 120/min.
The patient didn't tolerate the CPAP mask despite morphin injection. The CPAP mask was removed and replaced by a normal mask with 3l/min O2. After 10 min., patient became unconscious and O2 Saturation decreased. At the same moment blood pressure reduced enormously despite high noradrenaline rate. Patient was intubated and CPR was carried on but was unsuccessful.
Was the 500 ml fluids postoperative the reason of the detoriaration of her condition? How can someone balance between giving fluids (to compensate intravascular volume in sepsis) and at the same time watching out not to aggravate the pre-existing heart failure?
What could have be done better in managing this case?
81 year old patient came 2 days ago to the ER with renal colic and a hydronephrosis on the right side and urosepsis was diagnosed. Pre-existing ilnesses: chr. renal failure stage 4, chr. heart failure NYHA 2, multiple heart valve insufficiency.
Antibiotics (Cefuroxim) was started after taking blood cultures which showed presence of E.coli.
Yesterday morning noradrenaline per pump with a rate of 0.5 μg/kg/min and a lactate of 7. PCT 70 and CRP 200. Then an emergency operation to relieve the obstruction on the right side, where pus was seen flowing out of the obstructed ureter.
Postoperative the patient was tachypnic, instable with a heart rate of 150/min. Due to bed issues in our critical care the patient was transferred to the intermediate care, where she had a CPAP mask and 0.7 μg/kg/min noradrenaline. Fluids were running on the rate of 200 ml/h. After noticing that urine output was nearly 0, 40 mg Lasix were administered, which didn't bring any benefit. Then 500 ml fluids over 20 min. were administered which afterwards the heart rate reduced to 120/min.
The patient didn't tolerate the CPAP mask despite morphin injection. The CPAP mask was removed and replaced by a normal mask with 3l/min O2. After 10 min., patient became unconscious and O2 Saturation decreased. At the same moment blood pressure reduced enormously despite high noradrenaline rate. Patient was intubated and CPR was carried on but was unsuccessful.
Was the 500 ml fluids postoperative the reason of the detoriaration of her condition? How can someone balance between giving fluids (to compensate intravascular volume in sepsis) and at the same time watching out not to aggravate the pre-existing heart failure?
What could have be done better in managing this case?
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