Cervical fusions with remi

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RBA

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I'm in private practice. We just started doing spine cases. I seem to have problems- moreso with the cervical fusions - getting the patient to stop fighting the vent. Today I ultimately used dip 200mcg/kg/min + remi .1 up to .7m/k/m + 1/2Mac Des + Sufenta 150mcg in a 3 hour case. Despite all this, he was occasionally taking a BIG deep breath as I was hand ventilating. Any thoughts or has this situation ever come up with anyone else? I guess I could just use more remi, but it boggles my mind when people Talk of doing these cases without remi???
Does anyone use Alfenta for these cases?
I was shocked that after that much sufenta I still couldn't ventilate him more than 200cc tidal volumes.
 
what kind of cervical cases? why can't you paralyze? patients on chronic narcs? regardless, your doses are extremely high...we generally TIVA for neuromonitoring only and usually keep our propofol to 75 -150 mcg/kg/min and remi at 4mcg/kg bolus then 0.2-0.3mcg/kg/min (or sufenta 100 mcg bolus then 0.2mcg/kg/h) when we do TIVA. otherwise, i'd do 1/3 - 1/2 mac des with the sufenta as above or 20mg morphine or 2-3 mg of dilaudid pushed while awake to assess response.
 
what kind of cervical cases? why can't you paralyze? patients on chronic narcs? regardless, your doses are extremely high...we generally TIVA for neuromonitoring only and usually keep our propofol to 75 -150 mcg/kg/min and remi at 4mcg/kg bolus then 0.2-0.3mcg/kg/min (or sufenta 100 mcg bolus then 0.2mcg/kg/h) when we do TIVA. otherwise, i'd do 1/3 - 1/2 mac des with the sufenta as above or 20mg morphine or 2-3 mg of dilaudid pushed while awake to assess response.

yeah, those doses are pretty high.

we use the same doses as above here. maybe you're having trouble with breathing early on in the case with TIVA? usually gotta bolus the propofol or start at higher doses to get the plasma level up... otherwise it'll take em 30min to settle down...
 
I'm in private practice. We just started doing spine cases. I seem to have problems- moreso with the cervical fusions - getting the patient to stop fighting the vent. Today I ultimately used dip 200mcg/kg/min + remi .1 up to .7m/k/m + 1/2Mac Des + Sufenta 150mcg in a 3 hour case. Despite all this, he was occasionally taking a BIG deep breath as I was hand ventilating. Any thoughts or has this situation ever come up with anyone else? I guess I could just use more remi, but it boggles my mind when people Talk of doing these cases without remi???
Does anyone use Alfenta for these cases?
I was shocked that after that much sufenta I still couldn't ventilate him more than 200cc tidal volumes.

Here's my spine recipe. I do peds spinal fusions all the time.
Mask induction with sevo/n2o/02, access, propofol 2-3 mg/kg, intubate.
More access as needed, 2nd iv, aline, +/- central line.
Start infusions, gas off. Prep for flip.
Ketamine bolus 1mg/kg, flip.
+/- iv methadone.
TIVA starts with
-propofol at 200 mcg/kg/min. Titrate down to 100 or 125 based on input from neuro monitoring crew and BP.
-remifentanil at 0.2 mcg/kg/min. This is the drug I titrate the most. I also program 0.5 mcg/kg bolus on the pump.
-ketamine 0.1 mg/kg/hr. This runs in the background until about 30 min out.
As soon as they are done w/ the neuro monitoring, I work I some morphine for emergence and stop the ketamine and propofol and add Des. (may use fentanyl if methadone is onboard)
Works great. I don't know why you are having trouble, or why you are hand ventilating? If they are chronic pain patients, you will need a lot more remi, and the ketamine may help you a lot.
Just drop the gas and go with a tiva. Easy and improved signals as well. I don't understand why some feel the need for a volatile agent for these neuro monitoring cases.
 
Here's my spine recipe. I do peds spinal fusions all the time.
Mask induction with sevo/n2o/02, access, propofol 2-3 mg/kg, intubate.
More access as needed, 2nd iv, aline, +/- central line.
Start infusions, gas off. Prep for flip.
Ketamine bolus 1mg/kg, flip.
+/- iv methadone.
TIVA starts with
-propofol at 200 mcg/kg/min. Titrate down to 100 or 125 based on input from neuro monitoring crew and BP.
-remifentanil at 0.2 mcg/kg/min. This is the drug I titrate the most. I also program 0.5 mcg/kg bolus on the pump.
-ketamine 0.1 mg/kg/hr. This runs in the background until about 30 min out.
As soon as they are done w/ the neuro monitoring, I work I some morphine for emergence and stop the ketamine and propofol and add Des. (may use fentanyl if methadone is onboard)
Works great. I don't know why you are having trouble, or why you are hand ventilating? If they are chronic pain patients, you will need a lot more remi, and the ketamine may help you a lot.
Just drop the gas and go with a tiva. Easy and improved signals as well. I don't understand why some feel the need for a volatile agent for these neuro monitoring cases.


Cool. How do you determine who will get it (tolerant paitents?), how do you dose it. I have little experience with it.
 
We do 1000 neuro-spine cases a year (plus I don't know how many ortho-spine). I've considered cervical fusions to be the easy spines.
Normal cocktail (I don't like remi):
IV induction, 1/2 mac of volatile (normally iso but sometime des) + 50% nitrous. Usually have given 150-200mcg of fentanyl by incision. I like to give hydromorphone (usually around 1mg) a bit before they start closing.
Paralysis depends on neuromonitoring. If SSEP only, then I keep them well relaxed. If SSEP + MEP I'll do an infusion and coordinate twitches with the neuromonitor tech (2-3 twitches and they are happy). I only switch to TIVA if we lose signals.

For the opioid tolerant patients, I like to give a bolus challenge with them (how many mcg of fentanyl does it take for them to feel different) prior to induction. Helps give an idea on tolerance. I definitely wouldn't use remi for those patients, but ketamine, sufentanil infusion (bolus is useless, I think) or methadone is a better option.

I mostly use methadone for adolescent idiopathic scoliosis. 0.1mg/kg, 2/3 of it around induction, 1/3 about 1 hour before the end of the case. Works beautifully.
 
We do 1000 neuro-spine cases a year (plus I don't know how many ortho-spine). I've considered cervical fusions to be the easy spines.
Normal cocktail (I don't like remi):
IV induction, 1/2 mac of volatile (normally iso but sometime des) + 50% nitrous. Usually have given 150-200mcg of fentanyl by incision. I like to give hydromorphone (usually around 1mg) a bit before they start closing.
Paralysis depends on neuromonitoring. If SSEP only, then I keep them well relaxed. If SSEP + MEP I'll do an infusion and coordinate twitches with the neuromonitor tech (2-3 twitches and they are happy). I only switch to TIVA if we lose signals.

For the opioid tolerant patients, I like to give a bolus challenge with them (how many mcg of fentanyl does it take for them to feel different) prior to induction. Helps give an idea on tolerance. I definitely wouldn't use remi for those patients, but ketamine, sufentanil infusion (bolus is useless, I think) or methadone is a better option.

I mostly use methadone for adolescent idiopathic scoliosis. 0.1mg/kg, 2/3 of it around induction, 1/3 about 1 hour before the end of the case. Works beautifully.


Pretty similar ours minus the methadone and add sufenta or remi gtt depending on the attending.
 
🙁

Despite the obvious benefits of using remifentanil for these cases, I do not use it. These can be painful cases (for the patient and anesthesiologist) and the literature illustrates that these patients may have higher post-op pain requirements when their maintenance anesthetic includes remifentanil. My personal preference is to replace remifentanil with a sufentanil or fentanyl infusion. See link below for further discussion.

http://www.anesthesia-analgesia.org/cgi/content/abstract/102/6/1662
 
🙁

Despite the obvious benefits of using remifentanil for these cases, I do not use it. These can be painful cases (for the patient and anesthesiologist) and the literature illustrates that these patients may have higher post-op pain requirements when their maintenance anesthetic includes remifentanil. My personal preference is to replace remifentanil with a sufentanil or fentanyl infusion. See link below for further discussion.

http://www.anesthesia-analgesia.org/cgi/content/abstract/102/6/1662

horsesh ite. that study is ill-conceived, as are most postulating acute opioid tolerance from remi infusions.

think about it. 2 groups of kids.

1st group gets intermittent bolusses of morphine for spine case (long-acting narcotic).

2nd group gets remi infusion (super short-acting narcotic), turned off at end of spine case.

2nd group, drum roll.... requires more in the way of PCA morphine for post-op pain control.

NOT because of "acute opioid tolerance". Because they have zero long-acting narcotic on board. This is the confound behind the entire "remifentanil induced acute opioid tolerance" conspiracy.

these are painful cases. so you better dose some long-acting drug before you turn off the remi infusion. i do like methadone for opioid-tolerant patients, and hydromorphone for opioid naive patients.
 
horsesh ite. that study is ill-conceived, as are most postulating acute opioid tolerance from remi infusions.

2nd group gets remi infusion (super short-acting narcotic), turned off at end of spine case.

Slavin did you read the article? The abstract doesn't adequately detail the study design. This illustrates why we should do more than read the abstract:

Both groups received 100mcg/kg of morphine on induction, the morphine group had intermittent 50mcg/kg boluses. The remi group had morphine 100mcg/kg 30 minutes prior to the end of surgery.

I think remifentanil definitely induces acute opioid tolerance and likely hyperalgesia. There are multiple studies across several patient and operative populations that show high pain scores and greater opioid consumption in patients who received remi. Remi has a role in anesthetic practice, but I choose not use it for cases who undergo painful procedures. I also don't chase hemodynamics with opioids, assuming an adequate plane of anesthesia (pain is conscious emotion). I prefer to time opioids to peak with emergence. I've found that I use much less drug this way, patients are just as comfortable and not nearly as sedated. The exception is when I use sufentanil, but that drug has unique pharmacokinetic properties. Just one way to skin the cat.
 
We do a lot of spine cases and I do full TIVA on all of them mostly just to do something different from other cases. Most of my partners mix in some gas. I also rarely use remi unless I can't keep them still which doesn't happen. I use sufenta infusion. But honestly, I don't think that the cervicals are as stimulating or as painful as the lumbars or thoracic spines. So therefore, I think remi is fine for these cases due to the hyperalgesia risk being pretty low with cervicals. With that being said I still cover them with some longer acting narc at the end of the case. Don't underestimate the effectiveness of a good LTA to the cords and trachea.

The only other thing is that I use ketamine in the opiate tolerant and Mg in everyone.

Personally, the cervicals are the easier spine cases.
 
I'm in private practice. We just started doing spine cases. I seem to have problems- moreso with the cervical fusions - getting the patient to stop fighting the vent. Today I ultimately used dip 200mcg/kg/min + remi .1 up to .7m/k/m + 1/2Mac Des + Sufenta 150mcg in a 3 hour case. Despite all this, he was occasionally taking a BIG deep breath as I was hand ventilating. Any thoughts or has this situation ever come up with anyone else? I guess I could just use more remi, but it boggles my mind when people Talk of doing these cases without remi???
Does anyone use Alfenta for these cases?
I was shocked that after that much sufenta I still couldn't ventilate him more than 200cc tidal volumes.

I think theres nothing wrong with your coctail, you just had a guy out of the two sigma range. I think propofol + sufent works great, hyperventilate on volume control. Ketamine infusion might help, but Ive never seen a difference. If you have a quick surgeon, the hardest part will be timing the propofol. If he's slow, you can switch to agent if you prefer. Never had a problem with sufent, so I havent used remi, but dont see anything wrong with it.
 
Slavin did you read the article? The abstract doesn't adequately detail the study design. This illustrates why we should do more than read the abstract:

Both groups received 100mcg/kg of morphine on induction, the morphine group had intermittent 50mcg/kg boluses. The remi group had morphine 100mcg/kg 30 minutes prior to the end of surgery.

I think remifentanil definitely induces acute opioid tolerance and likely hyperalgesia. There are multiple studies across several patient and operative populations that show high pain scores and greater opioid consumption in patients who received remi. Remi has a role in anesthetic practice, but I choose not use it for cases who undergo painful procedures. I also don't chase hemodynamics with opioids, assuming an adequate plane of anesthesia (pain is conscious emotion). I prefer to time opioids to peak with emergence. I've found that I use much less drug this way, patients are just as comfortable and not nearly as sedated. The exception is when I use sufentanil, but that drug has unique pharmacokinetic properties. Just one way to skin the cat.

yup, i read it. you're right, i oversimplified things a bit to make my point. when i say the study was ill-conceived, i mean that the right way to do it would have been to give both groups of kids THE SAME intraoperative dosing of morphine, with one group ALSO receiving a remi infusion. Then, only then, look at post-op morphine usage. the way they did it completely neglects the differences in total dosages of morphine given to both groups. I'm saying that that difference alone could possibly account for the difference in post-op morphine use - not some "acute opioid tolerance" secondary to remifentanil. this illustrates why we should interpret studies correctly identifying weaknesses in study design and using our basic knowledge of pharmacology to question conclusions, and also illustrates why we should read papers on both sides of every coin.

this is the catch-22 inherent in all remifentanil "acute opioid tolerance" studies. remi does make it more difficult to gauge how much long-acting narcotic to work in before the end of the case, and this is the reason (i believe) for the higher pain scores and higher opioid consumptions reported at the end of cases using remi.

even so, there is a lot of controversy on this issue. there are equal numbers of studies with contradictory results on the topic of remifentanil hyperalgesia and so called "acute opioid tolerance". see below, for example..

No evidence for the development of acute tolerance to analgesic, respiratory depressant and sedative opioid effects in humans.
Angst MS, Chu LF, Tingle MS, Shafer SL, Clark JD, Drover DR.
Pain. 2009 Mar;142(1-2):17-26. Epub 2009 Jan 9.


i'm not aware of any study demonstrating acute opioid tolerance after remi infusion at the cellular level in humans. until i see it, and until some consensus is reached in the literature - i choose not to believe in it.

i turn remi off a good hour before the end of spine cases, and start dosing long acting narcotics, even in pins. seems to give good results, but i am still a resident and have limited experience..
 
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Slavin did you read the article? The abstract doesn't adequately detail the study design. This illustrates why we should do more than read the abstract:

Both groups received 100mcg/kg of morphine on induction, the morphine group had intermittent 50mcg/kg boluses. The remi group had morphine 100mcg/kg 30 minutes prior to the end of surgery.

I think remifentanil definitely induces acute opioid tolerance and likely hyperalgesia. There are multiple studies across several patient and operative populations that show high pain scores and greater opioid consumption in patients who received remi. Remi has a role in anesthetic practice, but I choose not use it for cases who undergo painful procedures. I also don't chase hemodynamics with opioids, assuming an adequate plane of anesthesia (pain is conscious emotion). I prefer to time opioids to peak with emergence. I've found that I use much less drug this way, patients are just as comfortable and not nearly as sedated. The exception is when I use sufentanil, but that drug has unique pharmacokinetic properties. Just one way to skin the cat.

opioids, in general, can induce hyperalgesia, thought to be related to modulation of descending inhibitory pain pathways. pain is not a conscious emotion, it is the subjective experience of nociception. nociception is a biologic process (with downstream physiologic effects) that occurs independent of consciousness.

"adequate plane of anesthesia" is a relative term, and as you'll note, opioids decrease the amount of inhalational agent necessary to acheive an adequate plane of anesthesia. if you give enough opioids, you won't have to "chase hemodynamic changes" with opiods because you will have a huge buffer of nociceptive control to attenuate changes in surgical stimulus. finally, if you give enough opiods you can get your end-tidal dry-cleaning fluid concentrations low enough (at low flows, of course) that, even for a ten hour case, you can get your agent of quickly with the patient breathing spontaneously, allowing you to further titrate your opioid dose.

if you haven't done this, i encourage you try it for any 2 or 3 hour case (neck, lap chole, gyn case): patient in room, hook up o2sat. 10 mg morphine or 1 mg dilaudid. hook up rest of monitors and assess response. give second 10 or 1 mg dose. induce. titrate opioids to et agent of 0.5MAC or to hemodynamic response. get breathing spontaneous and titrate opioids. blow off gas. most patients will open their eyes with the tube in their mouth and respond nicely if you ask them if they want the tube out. the key is minimizing the amount of agent you give.
 
I'm in private practice. We just started doing spine cases. I seem to have problems- moreso with the cervical fusions - getting the patient to stop fighting the vent. Today I ultimately used dip 200mcg/kg/min + remi .1 up to .7m/k/m + 1/2Mac Des + Sufenta 150mcg in a 3 hour case. Despite all this, he was occasionally taking a BIG deep breath as I was hand ventilating. Any thoughts or has this situation ever come up with anyone else? I guess I could just use more remi, but it boggles my mind when people Talk of doing these cases without remi???
Does anyone use Alfenta for these cases?
I was shocked that after that much sufenta I still couldn't ventilate him more than 200cc tidal volumes.

Thanks to everyone for their ideas! I am most appreciative.
In reading people's comments I see at least a few things that I did wrong.
First some additional info:
1-----Pt is on high dose methadone
2---this surgeon monitors Ssep & Mep and doesn't want any muscle relaxants.

Initially I realize now that I was hypoventilating (etco2's 40-45). I just wasn't thinking about that I need to hyperventilate to control the ventilations. Although he wasn't overtly bucking, the surgeoned sensed an occasional spont inspiratory effort and complained in not so uncertain terms that this was unacceptable. I took the pt off the vent as I upped my narcotic infusion after a bolus. Unfortunately, I wasn't able to ventilate very easily or effectively so the etco2 went even higher with the occasional deep spont respiration. I'm not sure why I couldn't ventilate easier by hand, but in any case I should have put the pt back on the vent. I'm embaressed to admit that I was basically treating hypercarbia with narcotic. Just to go on, at the end of the case the pt is breathing spontaneously and easily. I took him to rr and within 15min he was extubated and very awake(complaining of neck pain).

I did 2 other cervical fusions and they did very well, but I had no problems ventilating them.

Next time:
I'm going to go higher on my infusions, initially.
Hyperventilate to control the ventilations from the get go.
 
pain is not a conscious emotion, it is the subjective experience of nociception. nociception is a biologic process (with downstream physiologic effects) that occurs independent of consciousness.

Pain absolutely requires a functioning cerebral cortex. Pain is a negative emotion that results from nociceptive input. Not all people experiencing nociceptive input have pain. See this thread, tenesma vs womansurg for more.

"adequate plane of anesthesia" is a relative term, and as you'll note, opioids decrease the amount of inhalational agent necessary to acheive an adequate plane of anesthesia. if you give enough opioids, you won't have to "chase hemodynamic changes" with opiods because you will have a huge buffer of nociceptive control to attenuate changes in surgical stimulus. finally, if you give enough opiods you can get your end-tidal dry-cleaning fluid concentrations low enough (at low flows, of course) that, even for a ten hour case, you can get your agent of quickly with the patient breathing spontaneously, allowing you to further titrate your opioid dose.

You describe an alternative, widely accepted anesthetic technique. I don't view volatile anesthetics as evil humors. As we know now, a primarily opioid based technique increases the risk of awareness (I aim for a MAC of at least 0.7 based on the NEJM study). I think waking up from nitrous-opioid is very smooth. My standard practice is to emerge with no volatile anesthetic detectable, using nitrous and opioid. Saving most of the opioid for the time when the patient emerges (and is able to feel pain) allows me to have the identical pain control while utilizing much less opioid. I think the amount and type of opioid administered intraoperative affects post operative pain and opioid consumption (simply, the more given intraop, the more they need postop). Sympathic mediated hemodynamic responses can be treated with volatile anesthetic, opioid administration, or autonomic agents. My preference is to not use opioids for this reason. There's really no material difference in emerging from 1.0 ET isoflurane vs 0.5 after 10 hours. BTW, I'm sure you know that flows have nothing to do with how much anesthetic is stored in the body, right?

if you haven't done this, i encourage you try it for any 2 or 3 hour case (neck, lap chole, gyn case): patient in room, hook up o2sat. 10 mg morphine or 1 mg dilaudid. hook up rest of monitors and assess response. give second 10 or 1 mg dose. induce. titrate opioids to et agent of 0.5MAC or to hemodynamic response. get breathing spontaneous and titrate opioids. blow off gas. most patients will open their eyes with the tube in their mouth and respond nicely if you ask them if they want the tube out. the key is minimizing the amount of agent you give.

Yes, I've done this, but I think 2mg of hydromorphone is excessive for a lap chole or most gyn cases in an opioid naive patient. I can get the identical comfortable wakeup by giving 50mcg before the patient emerges. Just a different style that I believe reduces post operative pain and opioid related complications.
 
Thanks to everyone for their ideas! I am most appreciative.
In reading people's comments I see at least a few things that I did wrong.
First some additional info:
1-----Pt is on high dose methadone
2---this surgeon monitors Ssep & Mep and doesn't want any muscle relaxants.

Next time:
I'm going to go higher on my infusions, initially.
Hyperventilate to control the ventilations from the get go.

In patients on chronic opioids, I would go with a ketamine infusion and just bypass the whole tolerance issue (and be sure the patient has gotten their methadone that morning). IV methadone also would help for post op. I think remi is pointless in these kinds of patients. Agree on the hyperventilation, I normally got in the low 30s.

MEPs in an non-relaxed patient in pins is dangerous, in my opinion. A paralytic infusion targeted to 3 twitches (by the neuromonitor) is a safer approach that still produces reliable signals. We've had serious adverse events to MEPs (tongue lacerations and worse) in patient who were not relaxed.
 
In patients on chronic opioids, I would go with a ketamine infusion and just bypass the whole tolerance issue (and be sure the patient has gotten their methadone that morning). IV methadone also would help for post op. I think remi is pointless in these kinds of patients. Agree on the hyperventilation, I normally got in the low 30s.

MEPs in an non-relaxed patient in pins is dangerous, in my opinion. A paralytic infusion targeted to 3 twitches (by the neuromonitor) is a safer approach that still produces reliable signals. We've had serious adverse events to MEPs (tongue lacerations and worse) in patient who were not relaxed.

hey proman, what rates do you run your ketamine infusions at? i'd like to try it, but seems like there's quite a variation in dosing out there..

unfortunately, the culture at my institution prohibits relaxation with MEPs, so gotta be pretty careful to get that bite-block nicely secured..
 
Its been a while since there has been a thread like this, and I see some names I haven't before.
Did a fair number of spine cases as a resident and continue to do them now in pp. As a resident, we almost always used Remi, until my third year. It is very easy to do a case with remi, no movt, quick wake ups for neuro checks etc. But we found, anectdotely (sp?), that those pts were hurting and requiring a lot of post op narcotics (esp. the scoliosis/harrington rod cases). Then the article came out that essentially supported that intuition. So we stopped using it on backs, but continued with necks, who didn't seem to be complaining as much.

Interestingly, at the academic center, it was almost always just SSEPs and rarely MEPs, if anything. The reason we were using the Remi wasn't just to prevent movt without NMB, but for the quick wakeup at the end.
I forgot, we also used a fair amount to Dex depending on the attending. Some thought this helped to avoid mov't without NMB. Based on one horrifying incident after taking over a case at 7pm where I continued with the day's anesthetic plan that included Dex, I disagree.

Anyway, now in pp, most of the surgeons are requesting MEPs, thus no NMB, and, interestingly, they still don't want the pt to move 🙂. Well, the techs insist on no more than 0.5 mac of volatile. Whatever.

Prior to the propofol drought, my pp recipe was:

Lido, fent (MEP techs insist no BZD), 2mg of vec to soften them up for positioning/defasiculation, then Prop, succ tube.
Sevo at approx 1.2-1.4 ET
Prop at 100-200 depending on BIS
Phenylephrine gtt to maintain a good BP without flooding the pt with fluids so the face/eyes/tongue don't swell up.
Fent 3mcg/kg the first hour, and 2mcg/kg for each hour after--maybe a little more or less depending on the pt's gestalt
Hyperventilation to etco2 of about 30 to blunt respiratory drive.

Breathing spontaneously during closing, then pull the tube deep with an oral airway in place. Titrating narcotic for a comfortable emergence.

Less sexy than the academic setting with remi, dex, ketamine, tiva etc. but it works well. Surgeons and pts happy. And it is something I can tell an AA to do without getting eye-rolls and passive-aggressive behavior in return. The phenylephrine gtt pisses them off, apparently they don't see the value in maintaining good bps for several hours. What the heck? Like this is so much trouble to set up one drip?
Pt is typically awake, moving all 4 in under 5 minutes of going supine or neck brace on.

Just curious, you guys doing the remi, dex, ketamine etc., at academic or pvt settings?

I did all that stuff for years, and honestly the outcomes seem just as good without it. But what do I know? I rarely do my own post-ops anymore😉

PS,
Last week doing a case myself (not supervising that day) with no prop (still not avail!) and Sevo at about 1.4 ET, I ended up using 57mLs of fent on a 5 hour 4 level ACDF. I was chasing my tail wondering if it was merely htn or pain. But the BP really only responed to more fent, about 250mcg q 30-45 mins. That sucker breathed spontaneously at the end, woke up right on time, moved, slapped him with 5ml of prop, some versed and dilaudid and brought him to the SICU to leave the tube in overnight at the surgeon's request.
I was sweating wondering if he'd ever wakeup and warned the surgeon we may need to wait a while, but we didn't. Made me look good.
 
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Just curious, you guys doing the remi, dex, ketamine etc., at academic or pvt settings?

I did all that stuff for years, and honestly the outcomes seem just as good without it. But what do I know? I rarely do my own post-ops anymore😉

PP. Yes. I don't surpervise, so no one rolls their eyes at me 😉. I use ketafol gtt. 4-8 gms of mag depending on length of the case. I like remi because I always know where I am narc wise. Turn off remi 15-20 minutes before I end the case and load up with HM/fent/ to etco2 >40 and RR of 6-10. Dex allows me to cut down on my prop/HM/fent/ketamine and they seem to wake up smoother/tend to be happier in pacu. As mentioned above, ketamine is great for opiod tolerant patients.

All that being said... the technique you describe works and costs a lot less.
 
We were taught during residency to run .5mg/kg first hour then .25mg/kg for each hour thereafter.
Or you can just do a bolus each hour--which in some ways is easier, avoids set up of an extra line and pump, but then you have to remember to do it and the levels aren't going to be as steady.
Tuck
 
It's been a while since I've done a ketamine infusion but I think it was something like 1mg/kg for induction then 50-100mcg/kg/min. From what I've found searching, this may be on the higher end. Miller lists 30-90mcg/kg/min without nitrous, 15-45 with.
 
It's been a while since I've done a ketamine infusion but I think it was something like 1mg/kg for induction then 50-100mcg/kg/min. From what I've found searching, this may be on the higher end. Miller lists 30-90mcg/kg/min without nitrous, 15-45 with.

I have great success with very low dose ketamine after a 1mg/kg bolus. Only 100 mcg/kg/hr.
However, these are peds cases and not chronic pain cases. I can usually get the propofol down to 100 or 125, with Remi between 0.1 and 0.5.
 
PS,
Last week doing a case myself (not supervising that day) with no prop (still not avail!) and Sevo at about 1.4 ET, I ended up using 57mLs of fent on a 5 hour 4 level ACDF. I was chasing my tail wondering if it was merely htn or pain. But the BP really only responed to more fent, about 250mcg q 30-45 mins. That sucker breathed spontaneously at the end, woke up right on time, moved, slapped him with 5ml of prop, some versed and dilaudid and brought him to the SICU to leave the tube in overnight at the surgeon's request.
I was sweating wondering if he'd ever wakeup and warned the surgeon we may need to wait a while, but we didn't. Made me look good.

57 mls of fentanyl on a 5 hour case? That seems a little, uh, excessive.

Why did the neurosurgeom want him tubed overnight?
 
Why sufenta v alfenta in your mind?
How long are your cases? LTA is still working?
"Mg for everyone". Do you mean magnesium or mo' phine?

Ketamine bolus only, bolus and drip? how much do you bolus?

hope the snow is good. Uggy rain here but I am cycling a lot...


We do a lot of spine cases and I do full TIVA on all of them mostly just to do something different from other cases. Most of my partners mix in some gas. I also rarely use remi unless I can't keep them still which doesn't happen. I use sufenta infusion. But honestly, I don't think that the cervicals are as stimulating or as painful as the lumbars or thoracic spines. So therefore, I think remi is fine for these cases due to the hyperalgesia risk being pretty low with cervicals. With that being said I still cover them with some longer acting narc at the end of the case. Don't underestimate the effectiveness of a good LTA to the cords and trachea.

The only other thing is that I use ketamine in the opiate tolerant and Mg in everyone.

Personally, the cervicals are the easier spine cases.
 
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