Chronic transplant rejection

[phd89]

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can someone explain the mechanism written in FA of : "class I MHC nonself is perceived by CTL's as class I MHC self presenting a non self antigen"

I have no clue what this means

 

[ohyeahbaby]

can someone explain the mechanism written in FA of : "class I MHC nonself is perceived by CTL's as class I MHC self presenting a non self antigen"

I have no clue what this means

if a cell is infected with a virus let's say, and it needs to be killed, how would the CTLs know that it needs to be killed? simple, it just uploads nonself antigens (for example, viral stuff) onto the MHC class I. A CTL passing by will notice that, and will kill it.

Now, lets say i take one of my CTLs, and put it inside you. My CTL doesn't know it's inside you. It still thinks it's inside me, and it still thinks it's protecting me. Therefore, whatever cells it sees in your body, it will think they are cells in my body. But if they were cells in my body, they would have MHC class I that are recognizable to it. So, since my CTL doesn't recognize your class I MHC, it will still think that it is in my body, but it will assume that those cells have been taken over and are displaying foreign antigens, indicating they have been taken over. So, it will kill them, thinking it is still in my body and that it's protecting me.

Been up all night so I hope I didn't butcher the concept.

 

[Allsta2003]

can someone explain the mechanism written in FA of : "class I MHC nonself is perceived by CTL's as class I MHC self presenting a non self antigen"

I have no clue what this means

Here's my interpretation, which may be what OhYeahBaby was saying...

A transplanted organ will display Class I MHC but it will be considered "non-self" from the host (its a different Class I MHC than the host has)

The hosts CTLs, when circulating, come across this different Class I MHC and they "think" its the host's Class I MHC displaying foreign antigen (not that its a different Class I MHC altogether) The CTLs react like they normally would against non-self antigen displayed on Class I MHC ---> chronic rejection

 

[phd89]

Here's my interpretation, which may be what OhYeahBaby was saying...

A transplanted organ will display Class I MHC but it will be considered "non-self" from the host (its a different Class I MHC than the host has)

The hosts CTLs, when circulating, come across this different Class I MHC and they "think" its the host's Class I MHC displaying foreign antigen (not that its a different Class I MHC altogether) The CTLs react like they normally would against non-self antigen displayed on Class I MHC ---> chronic rejection

ok so please tell me if I got it right; im used to the donor and recipient terms so will be using that

The transplanted organ cells will display Class I MHC which will be non-self (different) from the host's class I MHC. The recipients CTL's when circulating will come across this Transplanted organ cells with different Class I MHC think its the Recipients (hosts) Class I MHC displaying foreign antigens (not a different class I MHC altogether) and the CTL'd start attacking the organ perceived as Non-self Antigens

can someone sum it up in one sentance as:

So The Cytotoxic T cells think the tissue is a foreign antigen as by its Class I MHC and not an altogether different organ and will start attacking- will that work?