Claisen reaction

[dsony2284]

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I have no idea about these reactions, everytime i look at them i get confused and forget. Can anyone explain the basic way to do a claisen reaction and what it incorporates. I know im asking a lot since this is online.

Thanks.

 

[fancymylotus]

I have no idea about these reactions, everytime i look at them i get confused and forget. Can anyone explain the basic way to do a claisen reaction and what it incorporates. I know im asking a lot since this is online.

Thanks.

acetoacetic ester condensation is basically two mols of of esters with alpha-H's with a base that gives you beta-keto esters. since this is online and i cant draw it out, heres a picture.

 

[dsony2284]

wow thanks a lot man..u rock

 

[dsony2284]

abhishek and aishwarya....what a combo lol thanks again

 

[fancymylotus]

abhishek and aishwarya....what a combo lol thanks again

shes the most gorgeous thing alive and hes amitabh's son-perfect combo 🙂

good luck studying🙂

 

[Joey413]

Very nice

 

[kxb4777]

Does this require the same conditions you would see in an aldol condensation (excess base/acid or OH-/H2O)

 

[fancymylotus]

Does this require the same conditions you would see in an aldol condensation (excess base/acid or OH-/H2O)

I think so,dont crucify me if I'm wrong, I took the test last year and am rusty on my orgo. Here's an aldol picture,though.

 

[kxb4777]

Okay just looked it up...

It requires a strong alkoxide base (strong base would result in nucleophilic addition or substitution; alkaline prevents this) and a hydronium ion (which I imagine is used to protonate the leaving alkoxy group)

Hope that's right.