Clarification on BRCA1/2

[FutureDoc4]

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Okay, I want to make sure I got this right:

Only 10-12% of breast cancer is familial:

of that, 50% have BRCA1 mutation, 40% BRCA2 mutation (then there is a mixture of other mutations that make up the rest)

BRCA1 mutations are also found in other cancers such as ovarian cancer.

So, if I get the question asking me:

Which of the following mutation is most sensitive for the detection of familial breast cancer?
BRCA1

Or

Which of the following mutation is most specific for the detection of familial breast cancer?
BRCA2

Good? Any clarifications would be appreciated.

 

[FutureDoc4]

Selfish bump

 

[Mah]

BRCA2 should be more sensitive to breast cancer since BRCA1 is also present in Ovarian cancer, i think.

 

[username456789]

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