clinical trials

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Abilene

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Hi everybody,

Has anyone in here ever written a review paper on clinical trials? How do you evaluate/interpret the results from those trials? What do you base on to determine if the results from that trial is significant? Is there any good internet link that assists in writting a review paper?

Any advice is greatly appreciated! Thankx
 
Hi everybody,

Has anyone in here ever written a review paper on clinical trials? How do you evaluate/interpret the results from those trials? What do you base on to determine if the results from that trial is significant? Is there any good internet link that assists in writting a review paper?

Any advice is greatly appreciated! Thankx

I am assuming that you have covered the topic previously if they are expecting you to write a review paper and analyze the results. In general, you would look at the trial and evaluate if there was enough power, if the sample size was large enough, look at the p value, look for the way they analyzed the data (ex: intention to treat, only those that finished, etc), look at blinding, look at possible bias (esp. funding bias). This should ring a bell if you have already covered stats and clinical trials, but ifyou haven't then determining significance could be hard.
 
If you don't know where to start... this article might be a good starting point.

The CONSORT Statement: Revised Recommendations for Improving the Quality of Reports of Parallel-Group Randomized Trials
JAMA, Apr 2001; 285: 1987 - 1991.

http://jama.ama-assn.org/
 
Thanks for your input...

Alwaystired: Yes, I was taught last year about clinical trials: different kinds of tests, power, study designs...but I have never written any critique for any research study...and now I find myself in big trouble because I was never an ... adequate writter to begin with!😳

Letjin: The link you gave me was interesting. I was curious about "CONSORT", didn't know what it was, so I based on that article and did a search and found even a more helpful website that offers a checklist that includes steps on how to analyze a paper.

So, to those of you outthere who are also doing the same thing (I know there are a couple of you in here, hehe) ... try this link, and I hope it would help you as well

http://www.consort-statement.org/Statement/revisedstatement.htm#checklist

and click on "checklist"

...now I have to get back to my writing assignment....😴 😴 😴 ...in my sleep...
 
Review papers at the publication level is very difficult to write. First off, you need to have a reasonable expertise on the subject that you're writing about. With that said, you'll also need to know 'all' the trials related to that topic. Of course you're going to have to weed out the ones that were performed poorly or had major limitations in the study, but it doesn't mean that you ignore them. In fact, with review papers, you'll have to address them as such.

Now when you write the paper, make sure you have a clear focus for the objective. Are you summarizing the disease state? the newest therapies? changes in the algorithm? or is it a personal opinion?

So depending on the type of research paper you're writing may determine the amount of background literature search you're going to have to do.

Another method to writing a good review paper is to see if there are any current review papers on the subject. If there are, look at their references and see if you can come up with those independently. If you are somewhat well versed in the topic, you should immediately identify the ones that are significant.

I hate writing review papers. It takes way too much time and isn't regarded as original research. But it's nice when you're not actively in pursuit of tenure and just want a promotion. But I know that promotions are not based solely on review papers, so original research is more of a priority than review papers.

My advice, if you're an academic, don't waste your time writing a review paper unless you know what you're talking about or if a journal 'requested' you write one. Spend it doing research. But if you're a student, well, start those literature searches.


Good luck.
 
LW,

Thanks for sharing. yep, as a student, I have no choice but to write that paper. It is taking soooooo much time just to read and be able to figure out what on earth the trials are saying....the different types of test (most of which I've never heard), the thousands of abbreviations on each page, and the numbers and graphs and charts in the results section....They are driving me crazy!

I have lost so much hair these couple of days 😱 😱

I need to wish for a miracle to finish this annoying paper!

By that time I'd be bald! 😡
 
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