Step I CLL Question

[InHoc]

CLL - noted in FA to have warm Ab autoimmune hemolytic anemia... IgG right?.... Well, it also says that there are no antibody-producing B cells. To further that - it's known that virgin B cells don't go on to make plasma cells, resulting in hypogammaglobulinemia, where 50% patients die of infection.

What gives - how is there a IgG hemolytic anemia with no plasma cells?

Thanks.

 

[idq1i]

Not all your B cell clones are leukemic/cancerous

 

[InHoc]

Not all your B cell clones are leukemic/cancerous

thanks. seems a bit obvious now.

 

[hemoglobincell]

The bottom of page 211 in Goljan RR Pathology says "4. Immune hemolytic anemia (IHA) Example - cold type IHA in chronic lymphocytic anemia". So, is it warm or cold AIHA for CLL?