clonidine and hypertension

[jfgavina]

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well, I think clonidine exerts its hypertensive effects by stimulating peripheral alpha-1 receptors. in first aid (page 241 2011 edition) it is said "especially w/ renal disease, no decrease in blood flow to kidney"

what do they mean with this?

thanks in anticipation

 

[1badvette]

it activates presynaptic a2 adrenorecptors in the brain decreasing the norepinephrine release decreasing cardiac output and vascular tone ..

 

[jfgavina]

yeah I know, but what do they mean "hypertension especially w/ renal disease, no decrease in blood flow to kidney"

??

 

[Juis]

The third column is applications, not side effects, so clonidine can be used to treat hypertension in renal disease.

 

[jfgavina]

LOL too much study makes this.. of course, that makes much more sense right now