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ASA Advises No Longer Holding GLP-1 Agents Prior to Surgery for Most Patients
New guidance replaces earlier rec of a 1-week and 1-day hold of injectable and oral GLP-1 agents
the cliff notes answer to their “guidelines “ is “we really don’t know what the F we want to recommend”
That’s the honest truth.
It’s absolute garbage what guidance they are giving between the GI docs and anesthesia society and the obesity society.
They answer the questions how Supreme Court nominees answer questions how they would vote in particular cases. With non answers
To sum it up
“Proceed with your own best judgment”
Where does this article say to hold for 7 days?Seems ultimately pretty straightforward.
Hold for 7 days then proceed
If they don't hold, then liquid diet 24 hrs and proceed
If they don't do either, then cancel or RSI
Patients shouldn't be aspirating if they are head up, paralyzed and then intubated. Not enough positive abdominal pressure to push material up the esophagus. Unless they are massively obese or unusual scenario.
If the decision to hold GLP-1RAs is indicated given an unacceptable safety profile following shared decision-making in the preoperative period, the duration to hold therapy is unknown [7]. At this time, it is suggested to follow the original guidance of the American Society of Anesthesiologists, holding the day of surgery for daily formulations, and a week prior to surgery for weekly formulations [4]. All patients should still be assessed on the day of procedure for symptoms suggestive of delayed gastric emptying.Where does this article say to hold for 7 days?
The problem I have with the 24 hr liquid diet is it sounds like a specific carve out for the GI docs so they can still get their colons done under “mac” without holding meds (they are on a prep anyway).If the decision to hold GLP-1RAs is indicated given an unacceptable safety profile following shared decision-making in the preoperative period, the duration to hold therapy is unknown [7]. At this time, it is suggested to follow the original guidance of the American Society of Anesthesiologists, holding the day of surgery for daily formulations, and a week prior to surgery for weekly formulations [4]. All patients should still be assessed on the day of procedure for symptoms suggestive of delayed gastric emptying.
Going to be very difficult to personalize pre-op recommendations for each patient based on all of those qualifiers, assess risk of delayed gastric emptying, etc. Pre op care teams?? Where do those exist in PP
So I guess an additional option is to not hold and just have all of those patients be liquid diet 24 hrs.
Possibly.The problem I have with the 24 hr liquid diet is it sounds like a specific carve out for the GI docs so they can still get their colons done under “mac” without holding meds (they are on a prep anyway).
I think you are correct. It is all anecdotal, but I don't think anyone has studied it. I don't think the headline of the article corresponds at all with the source article and only mildly corresponds to the letter to the editor by Joshi et al.Possibly.
But I also never saw any actual data showing increased aspiration events.
Agreed.I think you are correct. It is all anecdotal, but I don't think anyone has studied it. I don't think the headline of the article corresponds at all with the source article and only mildly corresponds to the letter to the editor by Joshi et al.
This new source paper offers zero new science as best I can tell and the source paper that was multidisciplinary states that, if you have concerns, follow the original guidelines. The only bit of new information (which I already knew) is that high dose is likely a greater risk for delayed gastric emptying than the low dose for the drugs and that people who are new to the drug may be at a slightly higher risk.
As stated by others, we finally were getting some buy in on the issue and getting surgeons and GI docs to have their patients hold the meds. Now they wish for us to risk stratify them on all of these levels. The only ones who will see the patient in a timely manner to be able to risk stratify them will be the ones who are least willing or qualified to do so.
So, this new set of recommendations feels a lot like the old ones but with a little more freedom to not just cancel the patient if everyone is in agreement to go ahead. It may lead to a lot of patients getting ETT for screening colonoscopy and will likely lead to some complacency that will result in a few cases of aspiration.
The headline makes it sound as if they have new information and they are walking back the recommendations and no longer have concerns. I don't see that as the case at all.
We are trying to figure out a response to this at our place. It is a new headache that we should not have because, if you don't have new information, why are you making any new recommendations? It is not as if the original problem no longer exists.
I was trying to figure out the thread title. That makes more sense.Just poking my head into the thread to say it’s “ c’mon “
Not “common”
Further, the guidance notes withholding GLP-1 drugs only for obese and overweight patients could constitute bias or discrimination and should be avoided.
Ok, fixed it. Not sure why I thought it was spelled like that.Just poking my head into the thread to say it’s “ c’mon “
Not “common”
I saw that. It’s a ridiculous thing to put in a so-called scientific statement.One of my partners noticed this gem of a statement from the ASA -
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Most Patients Can Continue Diabetes, Weight Loss GLP-1 Drugs Before Surgery, Those at Highest Risk for GI Problems Should Follow Liquid Diet Before Procedure
Most patients should continue taking their glucagon-like peptide-1 (GLP-1) receptor agonists before elective surgery, suggests new clinical guidance released by the American Society of Anesthesiologists (ASA), American Gastroenterological Association, American Society for Metabolic and Bariatric...www.asahq.org
I mean, I get what they're saying, but common ASA.
I mean c'mon.
It’s like saying that we shouldn’t treat cancer patients with appropriate treatments because we don’t want to hurt their feelings by acknowledging that they have cancer.WTF? Don’t treat the morbidly obese differently because that might be considered bias or discriminatory? They’re fat with actual medical problems and special concerns directly related to their morbid obesity. Thats not bias, it’s reality. Who TF is writing this, some communication major from the community college?
At this time, it is suggested to follow the original guidance of the American Society of Anesthesiologists, holding the day of surgery for daily formulations, and a week prior to surgery for weekly formulations
Interesting.The way I read this originally is you skip your weekly dose AND THEN wait a week, which means waiting two weeks since last injection. .
In my judgement I’m cancelling the anesthetic not the procedure; but if GI thinks it’s low risk and wants to proceed I’m not going to stop them.the cliff notes answer to their “guidelines “ is “we really don’t know what the F we want to recommend”
That’s the honest truth.
It’s absolute garbage what guidance they are giving between the GI docs and anesthesia society and the obesity society.
They answer the questions how Supreme Court nominees answer questions how they would vote in particular cases. With non answers
To sum it up
“Proceed with your own best judgment”
Wow, that’s really surprising. I’m wondering what transpired to have them change their stance.
This is the correct way of intubating everyone, every time. Outside of the “maintain spontaneous ventilation” scenarios.Seems ultimately pretty straightforward.
Hold for 7 days then proceed
If they don't hold, then liquid diet 24 hrs and proceed
If they don't do either, then cancel or RSI
Patients shouldn't be aspirating if they are head up, paralyzed and then intubated. Not enough positive abdominal pressure to push material up the esophagus. Unless they are massively obese or unusual scenario.
Are you giving succ to everyone then? That's cruel.This is the correct way of intubating everyone, every time. Outside of the “maintain spontaneous ventilation” scenarios.
Every intubation. Head up, induction->paralytic-> tube. No masking unless you miss. KISS. And keep what’s in the stomach in the stomach.
No. Rarely use sux. Especially since sugammadex is available, much easier to use Roc for short cases. Don't want sux myalgia.Are you giving succ to everyone then? That's cruel.
I mask almost everyone because I give roc to almost everyone, and it takes a minute or so to work.
Masking doesn't really risk insufflating the stomach and creating an aspiration risk unless the patient is huge / bearded and edentulous / has an otherwise bad airway ... or if you suck at masking. 🙂
Are you giving succ to everyone then? That's cruel.
I mask almost everyone because I give roc to almost everyone, and it takes a minute or so to work.
Masking doesn't really risk insufflating the stomach and creating an aspiration risk unless the patient is huge / bearded and edentulous / has an otherwise bad airway ... or if you suck at masking. 🙂
Only time I ever give sux is in ECT. Completely agree it’s cruel.Are you giving succ to everyone then? That's cruel.
I mask almost everyone because I give roc to almost everyone, and it takes a minute or so to work.
Masking doesn't really risk insufflating the stomach and creating an aspiration risk unless the patient is huge / bearded and edentulous / has an otherwise bad airway ... or if you suck at masking. 🙂
You don’t use it for bowel obstructions?Only time I ever give sux is in ECT. Completely agree it’s cruel.
I don’t mask during that minute. I just stand there and chat up the room.Are you giving succ to everyone then? That's cruel.
I mask almost everyone because I give roc to almost everyone, and it takes a minute or so to work.
Masking doesn't really risk insufflating the stomach and creating an aspiration risk unless the patient is huge / bearded and edentulous / has an otherwise bad airway ... or if you suck at masking. 🙂
Fine yeah a true SBO I’d give sux
How about a recent full meal for an emergency case. History of previous aspiration and also gastroparesis?Fine yeah a true SBO I’d give sux
Probably not. Back up, lots and lots of roc. But I wouldn’t fault anyone for giving it in that scenario.How about a recent full meal for an emergency case. History of previous aspiration and also gastroparesis?
Fake news!! ASA says it’s safe!!The timing of this FDA advisory stating GLP1 meds may cause pulmonary aspiration during deep sedation and GA is certainty interesting given the ASA's determination that there's not enough information to make a recommendation, lol.
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New FDA Warning Added to Popular Weight Loss Drugs
www.webmd.com
Nov. 6, 2024 – The FDA has updated the labels for all GLP-1 weight loss drugs with a warning about pulmonary aspiration during general anesthesia or deep sedation. The affected drugs are liraglutide (Saxenda, Victoza), semaglutide (Ozempic, Rybelsus, Wegovy), and tirzepatide (Mounjaro, Zepbound).
“This was a safety-related labeling change for the glucagon-like peptide-1 receptor agonist product class,” an FDA spokesperson said.
ask pggpeople that against sux?
people that against sux? i use sux most of the time on folks. just prop sux tube. works great. patients wake up and go home happy