Complex orgo mechs suck!

Discussion in 'Medical Students - MD' started by realruby2000, Dec 2, 2001.

  1. realruby2000

    realruby2000 Senior Member
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    Oh man....i really hate these mechs...they're so long...so boring...so pointless. Does anyone know if I'll have to put up with memorizing long ass mechanisms in med school biochem or pharmacology?. am i going to have to know exactly how TPP decarboxylates alpha keto acids? im studying for my orgo 2 exam and it sucks sooo much, i pray that i dont have to put up with this again
     
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  3. Starflyr

    Starflyr Manic Faerie
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    You'll have to know, in general, how things work (TCA cycle, etc) but no, you will probably not be required to draw out the exchange of electrons unless your professor is sadistic. If you ever REALLY need to know something at that level of detail in your future practice, well, that's what books are for!

    Star
     
  4. guardian

    guardian Senior Member
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    We didn't have to draw out structures or draw out mechanisms. We just had to recognize given structures or reactions. There is alot to remember even with a biochemistry background. It'd sometimes be frustrating, spending several hours remembering a pathway and having only one question on it.
     
  5. Fix-it-Man

    Fix-it-Man Member
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    For me, Biochem: understand & memorize pathways and the interconnectedness of metabolic pathways, most importantly the relevance of pathways and cycles and systems to human diseases. No organic chemical mechanisms. Familiarity with structures of amino acids, sugars, and lipids.

    Pharm: understand the pharmacokinetics, pharmacodynamics, mechanism of action (which takes into account some basic understanding of the chemistry of analogues, transition states, active sites of enzymes)liver metabolism, and excretion of various chemotherapeutic agents. KNOW some structures, for the boards, of families of drugs, not individual ones, notably antibacterials and antivirals...Organochemical mechs, NO!!

    Retain orgo mechs for the MCAT through there maybe one or two Sn1 or E1 questions although you're more likely going to get NMR spectrums.

    Good Luck!!!!!!! :cool:
     
  6. realruby2000

    realruby2000 Senior Member
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    what exactly is pharmacokinetics, and pharmacodynamics ?
     
  7. cchoukal

    cchoukal Senior Member
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    you won't have to know orgo pathways, but it's good practice for the metabolic and signaling pathways you WILL have to know... Right now we're doing the MAP-kinase pathway, and there's about a dozen relavent proteins and everything's interconnected to something else. Ish.
     
  8. Fix-it-Man

    Fix-it-Man Member
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  9. Fix-it-Man

    Fix-it-Man Member
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    "...the group in which the drug is classified..." :D
     
  10. turtleboard

    turtleboard SDN Advisor
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  11. realruby2000

    realruby2000 Senior Member
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  12. Castro Viejo

    Castro Viejo Papa Clot Buster
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  13. Hannibal Gabriel

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    Memories of Biochem: there was this giant scary poster we used to walk by in the hallway every day called "Chemical Pathways of the Human Body", and it looked like a New York City road map. We all said, ha, boy, I'm glad I'll never have to memorize THAT whole thing.

    Later, as I was exiting my biochemistry final exam with that glazed, hollow-eyed look that a lot of concentration-camp survivors probably would recognize, I looked up at that poster, and I realized with great sadness and irony that, yes, I actually DID know most of that poster.

    The moral is: BCH sucks. How did I conceptualize it? Picture a giant wheel in the middle, spinning over and over. That's the Krebs Cycle. Everything either feeds into it somewhere or feeds off it somewhere.
     
  14. Amra

    Amra A Quiet Voice of Reason
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    :eek: All medicine is the clinical application of biochemistry though :eek:
     
  15. Gear

    Gear Junior Member
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    I couldn't agree more with Tim Wu's comments about memorization! One of my greatest med school disapointments is the realization that mostly (like 95%+) of what it takes to succeed is to memorize long 'grocery lists' of stuff. One of our biochem profs called med school a very "anti-intellectual" process - I agree. After all the hoops I jumped through to get here...
    You pre-meds reading this board better make sure you talk to LOTS of med students and really understand what you're getting into! If you think the 1st two years is going to be this great stimulating intellectual adventure, you're in for a rude suprise!
     
  16. youngjock

    youngjock Membership Revoked
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    how do you manage to memorize infos about 2500 drugs?!

    How long did it take you?
     
  17. lord999

    Pharmacist Faculty Moderator Emeritus 10+ Year Member

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    For me, two years for the USP-DI (pharmacy student). This is NOT as difficult as it seems, because most drugs work in class action. That is why you actually need to know some mechanisms. (I personally dare the claim that you actually memorized 3500 drugs from a book. Even if that was done, that was a miserable waste of time owing to the fact that dosage forms, therapeutics, and indications change monthly.)

    From organic chemistry, you need to take the following things with you:
    1. Given a compound, what will it tend to do in vivo? In what condtions?
    2. Given a situation, what chemicals will act different than "normal" and why? Can I use this to my advantage?

    Definitions:
    Pharmacodynamics: The actual functions, mechanisms, and negative functions (toxicology) of a drug substance.
    Pharmacokinetics: The study of absorption, how a drug becomes activated and at what concentration, and its elimination.

    I'm sorry you have to learn this BS; you won't use most of it. However, I would pay attention to any reaction that happens spontaneously at neutral PH (hydrolysis, the carbohydrate transition game, and shielding mechanisms), because that's how we sneak drugs through.
     

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