Could UWorld be wrong?

[pbnj003]

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So i came across a biochem question in uworld that basically asked which of the following was an allosteric activator of gluconeogenesis?

Acetyl CoA, Alanine, Citrate, OAA, Lactate, F2,6BP

The answer was Acetyle CoA. But I have just finished reviewing my biochem notes from Kaplan and in that it specifically says that its an obligate activator and not a allosteric one!

what should i go with?

 

[Chirurg]

So i came across a biochem question in uworld that basically asked which of the following was an allosteric activator of gluconeogenesis?

Acetyl CoA, Alanine, Citrate, OAA, Lactate, F2,6BP

The answer was Acetyle CoA. But I have just finished reviewing my biochem notes from Kaplan and in that it specifically says that its an obligate activator and not a allosteric one!

what should i go with?

true, the video lectures point out the same, obligate activator.
not quite sure, whether obligate and allosteric contradict each other.

 

[je355804]

So i came across a biochem question in uworld that basically asked which of the following was an allosteric activator of gluconeogenesis?

Acetyl CoA, Alanine, Citrate, OAA, Lactate, F2,6BP

The answer was Acetyle CoA. But I have just finished reviewing my biochem notes from Kaplan and in that it specifically says that its an obligate activator and not a allosteric one!

what should i go with?

I find it interesting that we have to learn facts such as that.... It seems so trivial. The bottom line is, does it really matter whether it's an "allosteric" or an "obligate" activator?

Why in the world isn't it enough to just know that citrate and acetyl-coa inhibit glycolysis and activate gluconeogenesis. Craziness I tell you.

EDIT: Did a little research, Acetyl-CoA does seem to be an allosteric activator of Pyruvate Carboxylase.

 

[pbnj003]

completely agree with how "trivial" it is

it does get frustrating I feel like it takes away from the "bigger picture" oh I could go on venting about some of the "craziness" but I shall refrain.

and thank you for the research tidbit. I hope it doesnt come down to the two though!

 

[colonelmustard]

So i came across a biochem question in uworld that basically asked which of the following was an allosteric activator of gluconeogenesis?

Acetyl CoA, Alanine, Citrate, OAA, Lactate, F2,6BP

The answer was Acetyle CoA. But I have just finished reviewing my biochem notes from Kaplan and in that it specifically says that its an obligate activator and not a allosteric one!

what should i go with?

I have found Kaplan to be incorrect in multiple instances. Their books have plenty of errors; I have yet to find an errata for all their mistakes.

 

[OveractiveBrain]

I have found Kaplan to be incorrect in multiple instances. Their books have plenty of errors; I have yet to find an errata for all their mistakes.

And yet, the river of correct information that can easily produce 250 pluses far outweighs the one or two questions you might get wrong because you used the service. Errors exist, certainly. Take the good with the bad and you shall succeed.