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Oh, it definitely does. It's a big problem in aviation.
I can imagine. I've only been involved with FAA stuff on the cognitive side, though, which I would fall on the side of overwhelming caution (e.g., dementia, sequelae of a TBI) and such. I got tangled up in this in my clinical work due to an anoxic injury that led to some pretty stark EF and attention issues. Definitely not someone I'd be comfortable flying a plane.
But, I know they're pretty tough on other MH stuff. I have a colleague who does a good deal of evals for MH prescription med waivers. Expensive.