Cyclin-CDK Complexes - Confusing Sentence in FA

[mclee0033]

On page 74 of FA 2013, under the definition of Cyclin-CDK Complexes it reads: "Must be both activated and inactivated for cell cycle to progress." Can someone explain what they mean by that? Thanks!

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[sharklasers]

i don't know the details of which ones are needed for what stages, but i think certain complexes need to be on to progress into a particular phase, but then in order to move on to the phase after that, those complexes need to be turned off and different ones need to be turned on.

hope this helps... until someone else can come in and give you a much better explanation

 

[Little Soldier]

i don't know the details of which ones are needed for what stages, but i think certain complexes need to be on to progress into a particular phase, but then in order to move on to the phase after that, those complexes need to be turned off and different ones need to be turned on.

hope this helps... until someone else can come in and give you a much better explanation

spot on, thats basically it.

 

[drstarter]

Will add on a bit:

After a stimulus, ex injury leads to tissue repair involving growth factors activating proto-oncogenes to produce Cyclin D and CDK. Remember CDK is dependent on cyclin to work without it would have very little activity. So once activated a complex is formed and it would phosphorylate RB gene causing the cell to enter S phase. And once the cycle is over the complex is inactivated. That's it really

Hope it helps!