depolarizing vs. nondepolarizing neuromuscular blocking agnets

[MudPhud20XX]

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Ok, so I never managed to really get these concepts while in school.

FA says depolarizing agent is succinylcholine that is an ACh agonist whereas, depolarizing are ACh antagonist. So is that the reason succinylcholine is depolarizing since it leads to depolarization whereas the antagonist doesn't do anything thus called nondepolarizing?

 

[Phloston]

Ok, so I never managed to really get these concepts while in school.

FA says depolarizing agent is succinylcholine that is an ACh agonist whereas, depolarizing are ACh antagonist. So is that the reason succinylcholine is depolarizing since it leads to depolarization whereas the antagonist doesn't do anything thus called nondepolarizing?

Succinylcholine causes desensitization essentially.

For the USMLE, you need to know it's the one that can cause increased movement before the paralysis. And it's also the one that has notably increased risk of malignant hyperthermia (the USMLE obsesses over that, with dantrolene, but in real life it's absurdly rare. I was working under an anaesthetist who said in ~25 years he had only used dantrolene once, and he's 'pretty certain' it was just a precaution for nebulous Sx rather than for an actual MH).

And be able to visualize the succinylcholine desensitzation in graph form. There are a few questions like that.