There are several kinds of research out there for pre-meds and med students to do--basic sciences (bench), translational (between basic sciences and clinical), clinical, other stuff like health services/epidemiology. In any research, if humans are involved then it needs to be looked at and approved by the appropriate IRB (the red tape brewmeister was referring to), and if animals are involved it needs to be looked at and approved by the IACUC. From my (limited) experience, it seems that pre-meds can more easily get involved with basic sciences research than clinical and med students can get involved with any type due to their different knowledge and experience bases. Also, med students tend to do clinical research because it allows them to contribute to the field they hope to go into, as well as better get to know (and thus get a great LOR from) people in that field. That being said, med students don't have to do clinical research or research in their chosen specialty for it to help them with their residency applications, any research tends to look great and many students don't even know what field they want to go into until 3rd or 4th year. OP--are you a med student looking to do research at your school or are you a pre-med looking to do research at a medical school? If you are going to be a med student, it is quite easy to get involved--many researchers are more than happy to get free labor from a motivated and knowledgable medical student. Just look at the research interests of faculty in a department that interests you at your school and e-mail a few to set up a meeting to talk about doing research. If you are a pre-med looking to do research its pretty much the same, but depending on your institution it may be difficult to find a good project and even more difficult to do clinical research.