Digoxin pharmacokinetics

[HereWeGo21]

Got a UWorld question that said that Digoxin is excreted primarily unchanged in the urine.

What? Like, what about all the p450 interactions with Digoxin I have heard about throughout my life??

Anyone have any insight into this?

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[masaraksh]

https://en.wikipedia.org/wiki/Digoxin#Pharmacokinetic_properties

You might be thinking about other interactions.

 

[HereWeGo21]

https://en.wikipedia.org/wiki/Digoxin#Pharmacokinetic_properties

You might be thinking about other interactions.

Right. I saw this, and so I suspected P-glycoprotein might be involved.

But is this to say that there is NO hepatic p450 interaction with digoxin? Maybe it's the case that the interactions I've learned about for Digoxin, which I thought were p450 interactions, are actually p-gp interactions. It is true, for example, that there's a lot of overlap between the drugs that interact with p-gp and those that interact with p450.

This seems like a drastic turn though and I don't know if I should go into the test with it.

 

[tasar1898]

Too much detail imho , they prolly gonna ask you about an old guy with shot kidneys that took an ''old medicine for the heart'' and now sees yellow or hypokalemia and digoxin

 

[EmetyreUSMLEStep1Tutor1]

Too much detail imho , they prolly gonna ask you about an old guy with shot kidneys that took an ''old medicine for the heart'' and now sees yellow or hypokalemia and digoxin

just got uworld question on this one, lol

 

[worldbeater]

Digoxin is associated with bradycardia as well, it's either the drug of choice for bradycardia or causes it, I forgot which one. Can anybody enlighten me with that UWorld question.