Diluting cefazolin
Started by PpfSuxTube
Tell him your nursing supervisor said it was OK.
Saline or LR for 10 years no issues
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So it can be injected into an IV carrier delivering NS, LR or plasmalyte?
Of course you can - we use LR for just about every IV and everything goes through it - fluid, blood, drugs, etc. We don't do the "you have to have a second IV because you have two antibiotics" nonsense.
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deleted87051
It might matter if it’s sitting in a bag while infusing over an hour or 3 hours but not when you mix it up and inject it in 30 seconds.
The kiwis and the Canadians say it’s compatible with everything and I believe them.
The kiwis and the Canadians say it’s compatible with everything and I believe them.
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Had a peds anesthesiologist tell me when I was a resident to reconstitute it in sterile water cause even that makes it slightly hypertonic, so reconstituting it in NS or LR makes it way too hypertonic. Seems reasonable for tiny veins but does it matter? Dunno
I only use sterile water as your partner says because as soon as the medication hits the veins it remains in a completely electrolyte free environment.
I think to be safe we may need to drain the blood and replace it with sterile water so we can be sure that cefazoline is not exposed to anything that is not recommended in the monogram. One problem though... when it reaches the tissue it might get in contact with things other than sterile water, so we need to figure out a way to avoid this violation of pharmacy policies.
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deleted875186
CEFAZOLIN FOR INJECTION, USP
dailymed.nlm.nih.gov
Package insert says dilute in sterile water for bolus, but also says you can dilute in 50 mL of LR or saline or various other IV fluids for infusion, so it is clearly compatible, may just not be isotonic if you take 2 grams and put in a 10 cc saline flush and push it.
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if this practice were causing phlebitis or sclerosis, I am confident that we’d know about it, as ancef is without question among the most commonly administered medication in ORs across the country.
Why dilute it at all? Just have the patient sniff it.
This is the reason for the manufacturer's recommendation.
I doubt it matters for the most part. Lots of the drugs we inject are anything but isotonic.
At the extreme end we've got 8.4% sodium bicarb, which has twice the osmolarity of 3% hypertonic saline, but I don't think anyone ever worries about giving that. You'd have to dilute a 50 mL amp of it in something like 350 mL of water to make it isotonic. Ain't nobody got time for that.
I actually draw my ancef up in 10cc of blood so I know its in its destination environment. Prove me wrong. Lol
They also recommend to give IV acetaminophen over 15 minutes and I boom that **** in like a beer bong.
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deleted87051
That’s why every patient deserves a cordis dumping into the SVC/RA junction 😉
Your blood or the patient's?
Why mix yourself when you can let the ancef pump in the chest do it for you!
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Careful, the surgeon might start thinking it's cocaine and want a hit himself.
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deleted87051
Check "Gahart's INTRAVENOUS MEDICATIONS, A Handbook for Nurses and Health Professionals", it has a perfect table at the end of it titled "Solution Compatibility Chart", you may see your medication is listed and both NS and R or RL are Compatible.
