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Kaplan micro explains that the early onset of Listeria monocytogenes in neonate is characterized by disseminated granulomas with central necrosis.
So I have some questions:
1. What is the significance of the word "disseminated" granulomas instead of just granulomas?
2. Pathoma explains that the difference between noncaseating and caseating granulomas is whether it exhibits "central necrosis" or not. If there is an absence of central necrosis, then it is noncaseating and if there is central necrosis, then it is defined as caseating granulomas.
So would you considered disseminated granulomas with central necrosis equivalent to caseating granulomas?
3. Also, can anyone explain what is going on in granulomas? I get that granulomas = epithelioid histiocytes = macrophages abundant with pick cytoplasm, but I am not sure what they really means in plain English. (I could have googled it and try to digest in my own words, but I would appreciate any insights from you guys....)
Many thanks in advance
So I have some questions:
1. What is the significance of the word "disseminated" granulomas instead of just granulomas?
2. Pathoma explains that the difference between noncaseating and caseating granulomas is whether it exhibits "central necrosis" or not. If there is an absence of central necrosis, then it is noncaseating and if there is central necrosis, then it is defined as caseating granulomas.
So would you considered disseminated granulomas with central necrosis equivalent to caseating granulomas?
3. Also, can anyone explain what is going on in granulomas? I get that granulomas = epithelioid histiocytes = macrophages abundant with pick cytoplasm, but I am not sure what they really means in plain English. (I could have googled it and try to digest in my own words, but I would appreciate any insights from you guys....)
Many thanks in advance