Reverse it, correct it, and resubmit it if you do not want the money for the claim to be recaptured by the insurance company.
Two years ago we had an auditor come into our store and he audited a brand Seroquel 200mg prescription. The directions on the prescription were "Take 1 to 2 tablets every day at bedtime", however, we wrote "Take 2 tablets every day at bedtime". The insurance company took back all the money for that claim.
It took us a while to fight it, and eventually we got a new prescription and a signed letter from the physician saying he wanted the patient to take 2 tablets at bedtime. It was a huge, unnecessary headache.
Insurance companies go for technicalities, and different directions on the prescription versus what was submitted will be a reason they recapture a claim.
We had insurance companies try to get back money because OxyContin scripts which we dispensed as BID were written as Q12. They wanted us to write every 12 hours. We also had companies try to take back money because did not write where fentanyl patches were being applied. The auditor said we were supposed to write "Apply 1 patch to acute chest well every 72 hours" instead of "Apply 1 patch every 72 hours".
Directions matter if you want to keep the money for the claim. I wouldn't bother with cheap drugs, but anything over $100, you bet I will reverse, correct, and resubmit.