Entresto to/from ACEI < 36 hrs
Thanks! Didn’t know this one
Entresto to/from ACEI < 36 hrs
Very true, some are stupid and end up saying “you should’ve called to clarify then” lmao. Yes, you shouldn’t be clear but we should call on everything. Excellent.OP, you need to have the mindset that prescribers don't know **** about what's stocked in the pharmacy or how dispensing works so turn it around on them in the rare event they try to stir **** up.
"I'm not a ****ing mind-reader"
"Don't put a DAW 1 if you didn't mean it"
etc etc.
Very true, some are stupid and end up saying “you should’ve called to clarify then” lmao. Yes, you shouldn’t be clear but we should call on everything. Excellent.
to CYA does it suffice that the doctor or his agent says that the doc wants to continue pt on this combo because pt has been on it for a while and can tolerate it? Just because they tolerate it now doesn’t mean they always will though? I’m saying this with regards to combos that are listed as contraindicated and pop up red in the system or on micromedex, lexicomp, etc as well as being listed as so in the package insert. I just have a hard time justifying dispensing contraindicated combinations because I always wonder what would happen if a pt ended up suing. Wouldn’t the package insert end up working against you since it clearly says not to give it together?
These are very good examples. I don’t think they can sue you for anaphylaxis to penicillin if they have NKDA listed in their profile. You’re not psychic nor are you responsible for something they weren’t even aware of.Fill an rx for penicillin and the customer has an anaphylactic reaction is bad. Do it without trying to record allergies, worse. Do it AFTER knowing about the allergy and NOT assessing risk horrible.
Fill a fentanyl patch rx for an opiate naive patient very bad.
Fill an new rxs for atovastation 80 and gemfibrozil 600mg bid for an elderly patient very bad.
Fill prometh with codeine for a 2 year old very bad
On the other hand, fill rx for penicillin for a customer after asking for allergies and none reported, then the patient developes anaphylaxis, bad for the patient and you still might get sued but you did your job.
Fill clozaril or isotretinoin rxs without checking appropriate databases very bad.
These are very good examples. I don’t think they can sue you for anaphylaxis to penicillin if they have NKDA listed in their profile. You’re not psychic nor are you responsible for something they weren’t even aware of.
For fentanyl patches it has its own requirement of having to be on a certain dosage of an opioid for at least a week. My rph, when I was an intern, would just check for any history of opioids without paying attention to the dose or whether it was recent or not..
If you get a fentanyl rx and its been a few days since they ran out of the other opioid, or a few weeks.. how do you determine whether they’re still considered tolerant or not? I haven’t found any info on that so it’s a gray area although I’m sure it won’t be likely that an opioid pt would wait for weeks between pick up of other opioid and current pick up of fentanyl.
Dont just put 'md said it's ok'... md needs relevant and specific clinical reasoning too that you as a pharmacist agree is reasonable... 'md said inx with warfarin is ok' vs 'md aware of inx and told pt to make inr appointment for this week to monitor'... or something
Are you saying that was considered sufficient? Idk anymore hahaThat's funny because at a small hospital where I worked, one of the choices was "MD aware" and most pharmacists didn't type any comments.
Oh darn you'd think it'd be like 'md aware and ok with X because Z' or somethingThat's funny because at a small hospital where I worked, one of the choices was "MD aware" and most pharmacists didn't type any comments.
Are you saying that was considered sufficient? Idk anymore haha
"Don't put a DAW 1 if you didn't mean it"
etc etc.
Tikosyn and Levaquin came to mind.Sure, if OP's co-workers are dispensing this and not documenting any intervention then shame on them. I'm just genuinely curious what contraindicated combos their co-workers are dispensing that gives them pause.
I do care about the Linezolid and SSRI interaction, and so do the good infectious disease doctors in my experience. They appreciate being called on that.Yeah I once worked with a pharmacist who would not dispense flomax and finasteride together because it is a therapeutic duplication. No joke.
How about linezolid with SSRIs? Personally I don’t usually object unless there are 3+ agents but I know some pharmacists who are significantly more conservative than that.
But I think most interactions are overrated. I mean how many DURs do you blow through in a day? Most of them are fake news.
Vanc + zosyn (although not absolute)Can you give some examples of "contraindicated combos"
Vanc + zosyn (although not absolute)
IM olanzapine + IM/IV bzd's
Pletal in the setting of heart failure (triggers if they are on entresto, etc)
colchicine + clarithyromycin
Combo's of DOAC (I mean this is obvious but I have seen surgeons order xarelto post op for VTE prophy and continue a patient's eliquis for afib
zosyn + vacn = high risk of AKI, no reason not to change to cefepime +/- flagyl depending on if anerobic coverage required.Huh? Your first two examples are appropriate for the right indications/circumstances
zosyn + vacn = high risk of AKI, no reason not to change to cefepime +/- flagyl depending on if anerobic coverage required.
IM olanzapine + iv/im bzd's is an absolute contraindication (cat x on lexi) due to high numbers of deaths if given within 1 hour.
I agree with what you say about clinical judgement - but was just point out examples - but I think we are on the same page. At my institution the PsA susceptibilities are similar with zosyn and cefepime.Disagree...
If your health-system has higher PsA susceptibilities with Zosyn over Cefepime I would favor that empirically for sepsis or risk factors for PsA (If such an antibiogram exists who knows). Monitor renal function closely and hold other nephrotoxic agents untilt he dust settles.
If you actually read into the warning on Lexicomp, the IM Olanzapine and parenteral BZD is based on case reports where a majority had polypharmacy in the background. Is it a first choice of mine for the excited delirium ED patient? No (Ketamine is). Is it more effective and just as safe as a B52? Probably.
Maybe my rhetoric with asking the OP for a "Contraindicated combo" isn't conveying well... my main point is that there are few absolute contraindications in pharmacy and not every drug interaction is black and white. If you don't use clinical judgement then what makes you better than your company's QA software?