My personal experience...
I'm an Arizona resident, but wouldn't mind returing to da bayou. So when I submitted my secondary to to LSU-NO, I included a letter to the adcom with a list of my Louisiana ties - the fact that I grew up there, went to high school and college and that many members of my immediate family still live there. I also included a list of all of my immediate family who are LSU alums - father, mother, grandmother (one of the first women to be granted a degree from LSU!) brother, uncles, aunts, cousins, etc, to show that I have ties not only to the state, but also the institution.
Finally, I also pledged a committment to serving Louisiana's underserved populations and practicing in that state, should I be accepted, which is actually what I do want to do.
Potentially overkill, but I want to make sure I have every shot at an interview. Something to consider...