Double Strand Breaks

[Jiller1994]

Can somebody walk me through exactly what this is? I keep seeing it on tests but I can't exactly grasp it totally. Is it when both the sense and antisense strand of DNA is split when it is undergoing a transfer of information as in a tetrad, or when the strands are simply split by damage, or...?

Any more info I should know/ if you can direct me would be awesome

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[swollcat]

DSB can happen for any number of reasons but they're often implicated in chemical damage, radiation, etc. What's more important to know is the way in which such breaks are repaired and their outcomes. I.E. homologous recombo - the more complete repair, DS end joining - the quick and dirty method, etc.