The most important complement-derived chemotactic factor
for neutrophils is:
C1
C3a
C4
C5a
C5b67
C5a is one of the most potent chemotactic factors known for inflammatory cells.20,21 Recently, specific C5a receptors (CD 88) have been characterized on human neutrophils41 and eosinophils.42 In human mast cells, C5a has been shown to induce histamine release from skin and heart mast cells,24-27 but not from lung mast cells.24 A recent study by Füreder et al43 using indirect immunofluorescence has shown the expression of C5a receptors on skin and heart mast cells, as well as on HMC-1 cells, but not on lung, uterus, and tonsillar mast cells. This mast cell heterogeneity regarding anaphylatoxin-induced activation might be of particular clinical relevance. In contrast to the well-defined biologic effects of C5a on many different cell types, little is known about the effects of C3a. Specific activation by C3a has been shown primarily for guinea pig platelets,14 guinea pig macrophages,44 human basophils,23,45 and human eosinophils.22 In addition, C3a has also been reported to induce histamine release from human skin mast cells24,26,43 and peritoneal rat mast cells.27,46
i think C5a is ans
Histologicallywhich pairs are similar?
Coagulative Necrosis - Liquefactive Necrosis
Caseation Necrosis - Coagulative Necrosis
Gummatous Necrosis - Liquefactive Necrosis
Caseation Necrosis - Liquefactive Necrosis
Caseation Necrosis - Gummatous Necrosis