Down Syndrome and Nondisjunction

[virtualmaster999]

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Hi all!

Quick question that I'd just like to double check on:

Down Syndrome can occur due to nondisjunction of chromosome 21 OR paired homologues in anaphase 1 or 2 right?

Thanks in advance!!

 

[whitepapertree]

http://www.sumanasinc.com/webcontent/animations/content/mistakesmeiosis/mistakesmeiosis.html

 

[cdp1210]

Yeah it can occur due to nondisjunction during anaphase I or II. It is more common from anaphase I though because 50% of the gametes would be n+1 whereas if nondisjunction occurs during anaphase II only 25% of the gametes would be n+1.

 

[virtualmaster999]

Thank you!

 

[premedpredent95]

Do we have to know any genetic disorders other than Downs' Syndrome? Ie. Turner's syndrome

 

[whitepapertree]

Do we have to know any genetic disorders other than Downs' Syndrome? Ie. Turner's syndrome

Edward = trisomy 18
klinefelter = XXY
turner = XO
downs = trisomy 21

are probably the only ones you need to know that regard aneuploidy.