Step I Drugs for step 1

[MudPhud20XX]

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Let's regurgitate names of the drugs hopefully this effort will help others who keep forgetting like me. I will start.

What is the name of the drug that is an alpha 1 blocker and mainly used for benign prostate hyperplasia?

 

[Transposony]

Unique side effect of the antiviral drug that is also used to treat Parkinson disease?

Not having to pay tax (Amantadine)

Q: Antibiotic which binds to surfactant?

 

[mcloaf]

Not having to pay tax (Amantadine)

Q: Antibiotic which binds to surfactant?

I was going to go with livedo reticularis.

Daptomycin.

 

[Transposony]

I was going to go with livedo reticularis.

That is a side effect stated in Wikipedia but Goodman & Gilman as well as Harrison does not even mention it and FA says ataxia as a S/E.
Also, Livedo reticularis is a vascular phenomenon while Amantadine has CNS side effects.
Wonder if it is just an urban legend!

 

[Macaroon_Berry]

Livido Reticularis - Amantidine

 

[seminoma]

Name of the recombinant-hormone drug that is used to treat osteoporosis (intermittent dosing)?

 

[seminoma]

Treatment for someone with chronic shortness of breath, a murmur that increases during hand grip, and an abnormal Schober test?

 

[Transposony]

Treatment for someone with chronic shortness of breath, a murmur that increases during hand grip, and an abnormal Schober test?

TNF-α inhibitors

 

[nidusiamnot]

Name of the recombinant-hormone drug that is used to treat osteoporosis (intermittent dosing)?

Salmon calcitonin

Rx when HIV pt is intolerant to ganciclovir?

 

[seminoma]

Salmon calcitonin

I'm not familiar with salmon calcitonin... The answer I was looking for was teriparatide (recombinant PTH).

Rx when HIV pt is intolerant to ganciclovir?

Foscarnet?

Treatment for lyme disease in a child?

 

[nidusiamnot]

I'm not familiar with salmon calcitonin... The answer I was looking for was teriparatide (recombinant PTH).



Foscarnet?

Treatment for lyme disease in a child?

Amox under 8 yo

Weight loss agent that works as an ATP uncoupler?

 

[ALUCSD18]

What resources are you using to study pharma? You guys are doing well answering all the questions.

 

[nidusiamnot]

What resources are you using to study pharma? You guys are doing well answering all the questions.

My bad, I thought you were looking specifically for that answer hah. It's used as a spray to treat hypercalcemia or osteoporosis. I guess I'm overthinking it as usual.

I used Raymon and nothing else for my pharm prep.

 

[seminoma]

What resources are you using to study pharma? You guys are doing well answering all the questions.

The usual suspects for me. Course notes, FA, Qbanks, Kaplan pharm lectures. Starting to flip through lange cards now too.

My bad, I thought you were looking specifically for that answer hah. It's used as a spray to treat hypercalcemia or osteoporosis. I guess I'm overthinking it as usual.

I used Raymon and nothing else for my pharm prep.

Is that salmon calcitonin thing in the Raymon Kaplan lectures?

 

[seminoma]

Amox under 8 yo

Weight loss agent that works as an ATP uncoupler?

Dinitrophenol.

Antineoplastic that causes peripheral neuropathy and has a blackbox warning against intrathecal use?

 

[nidusiamnot]

Dinitrophenol.

Antineoplastic that causes peripheral neuropathy and has a blackbox warning against intrathecal use?

The usual suspects for me. Course notes, FA, Qbanks, Kaplan pharm lectures. Starting to flip through lange cards now too.

wow you got me, i'd like to say the vinca's since one of them causes peripheral neuropathy.

Is that salmon calcitonin thing in the Raymon Kaplan lectures?

yeah I think Raymon covers it.


drug acting on GABA B receptors 🙂

 

[Paddles]

Dinitrophenol.

Antineoplastic that causes peripheral neuropathy and has a blackbox warning against intrathecal use?

Vincristine?

 

[seminoma]

yeah I think Raymon covers it.


drug acting on GABA B receptors 🙂

Damn, I better go watch it again then..

Baclofen.

Vincristine?

Yup!

Will be back with a question.

 

[faisal 2000]

treatment of hypertension in pregnant women has liver disease

 

[pathologyDO]

A drug you are administering for chemotherapy produces acrolein as a toxic byproduct after being metabolized by the liver. You know that this drug also produces phosphoramide mustard which is the active metabolite that works against tumor cells. What is the name of the major side effect produced by this drug? What is the drug?

 

[Macaroon_Berry]

A drug you are administering for chemotherapy produces acrolein as a toxic byproduct after being metabolized by the liver. You know that this drug also produces phosphoramide mustard which is the active metabolite that works against tumor cells. What is the name of the major side effect produced by this drug? What is the drug?

Cyclophosphamide, hemorraghic cystitis

 

[Macaroon_Berry]

The usual suspects for me. Course notes, FA, Qbanks, Kaplan pharm lectures. Starting to flip through lange cards now too.



Is that salmon calcitonin thing in the Raymon Kaplan lectures?

Sorry I just edited this because I remembered - Raymon from Kaplan Pharm lectures doesn't cover Calcitonin, but it was covered in the Calcium chapter in Kaplan Physio.

 

[Macaroon_Berry]

Amox under 8 yo

Weight loss agent that works as an ATP uncoupler?

I think DNP.. dinitrophenol?

 

[pathologyDO]

Cyclophosphamide, hemorraghic cystitis

Yes, that's correct!

 

[Pedantic]

treatment of hypertension in pregnant women has liver disease

hydralazine?

 

[faisal 2000]

hydralazine?

yes, you are right.you have to avoid methyldopa in this case. you can also use labetolol or nifedipine.

hydralazine may increase risk of (sle) like procainamide, quinidine, acebutolol, penicillamine, isoniazid, and chlorpromazine

 

[Pedantic]

What are (at least) two reasons why heparin is not used for long term anticoagulation?

 

[Kuvan]

Atropine/pralidoxime



Protease inhibitor that causes kidney stones?

Indinavir? I haven't dispensed it for ages.

 

[Kuvan]

prazosin

Prazosin is almost never used for BPH. It's used for PTSD coz it helps with nightmares. The alpha-blockers that are commonly used for BPH are tamsulosin, alfuzosin, silodosin, terazosin, and doxazosin.

 

[Kuvan]

Timolol -beta agonist
Pilocarpine - anti muscarinic

Will be back to ask questions.

Pilocarpine isn't an antimuscarinic agent. If it were, it wouldn't be used for someone with Sjogren's syndrome (brand name for tablet is Salagen). If it were an antimuscarinic, it would dilate the pupils and worsen closed angle glaucoma. It's a muscarinic agent. Hope that helps.

 

[Kuvan]

1. Palivizumab
2. Protease inhibitors (-navir) except atazanavir
3. Clomiphene

We can also use metformin, right?

 

[Kuvan]

You were right on 2, that's what I was asking. I guess I should have said "pair" instead of "combo."

We also have the expensive HCV drugs now - Boceprevir, simeprevir, Sofosbuvir, and telaprevir (off the market). The newest PO combo for HCV is ledipasvir+sofosbuvir (Harvoni).

 

[Kuvan]

Phenobarb?

The old generation antiepileptics should be avoided. They cause birth defects. Levetiracetam?

 

[Kuvan]

What are (at least) two reasons why heparin is not used for long term anticoagulation?

HIT?

 

[Kuvan]

DOC for chronic stable angina?

 

[Kuvan]

Which agent for angina that doesn't affect the contractility of the heart or the heart rate?

 

[Kuvan]

Name 3 P2Y12 inhibitors. Which 2 are prodrugs? Which one can't be combined with ASA over 100mg/day?

 

[Kuvan]

If a pt was given fondaparinux and was being sent to cath lab to have PCI, the pt would need (because the pt's not adequately anticoagulated)?

 

[Kuvan]

Which agent is used for bedwetting and can also be used to promote the release of vWF?

 

[Kuvan]

Which antiarrhythmias can be used for cardioversion for pts with AF up to 7 days? DIP-AF (mnemonic). Which 3 are effective for cardioversion (still talking about AF) after 7 days?

 

[Kuvan]

A drug you are administering for chemotherapy produces acrolein as a toxic byproduct after being metabolized by the liver. You know that this drug also produces phosphoramide mustard which is the active metabolite that works against tumor cells. What is the name of the major side effect produced by this drug? What is the drug?

Ifosfamide?

 

[Kuvan]

Cyclophosphamide, hemorraghic cystitis

And we use Mesna to bind to acrolein.

 

[Kuvan]

I'm not familiar with salmon calcitonin... The answer I was looking for was teriparatide (recombinant PTH).

Miacalcin isn't very efficacious, so it's not 1st line therapy. First lines are bisphosphonates and denosumab.

 

[Kuvan]

What are (at least) two reasons why heparin is not used for long term anticoagulation?

My bad, I said HIT just now. I think it's osteoporosis and it'll screw up someone potassium level. I think. HA!

 

[pathologyDO]

And we use Mesna to bind to acrolein.

yep!

(1) You place a patient that has Hodgkins lymphoma on a chemotherapy regimen consisting of 4 drugs which do NOT have overlapping side effects. One of these drugs causes the patient to have accelerated heart rate and wheezing. Which drug is it? What are the 4 drugs administered?

(2) Later in the clinic you see a patient with non-Hodgkins lymphoma and treat them, again, with a 4 drug chemotherapy regimen. This patient has serious nausea and vomiting before entering the 2nd treatment. Which drug class would be used to treat this condition if it were due to anticipatory emesis? If the patient had high emetic risk following chemotherapy, what would you use to treat it? (Hint: 3 drugs)

 

[Kuvan]

yep!

(1) You place a patient that has Hodgkins lymphoma on a chemotherapy regimen consisting of 4 drugs which do NOT have overlapping side effects. One of these drugs causes the patient to have accelerated heart rate and wheezing. Which drug is it? What are the 4 drugs administered?

(2) Later in the clinic you see a patient with non-Hodgkins lymphoma and treat them, again, with a 4 drug chemotherapy regimen. This patient has serious nausea and vomiting before entering the 2nd treatment. Which drug class would be used to treat this condition if it were due to anticipatory emesis? If the patient had high emetic risk following chemotherapy, what would you use to treat it? (Hint: 3 drugs)

I don't know much about cancer, but I do know that when a drug is highly emetogenic (i.e., cisplatin), you use ondansetron (or any 5HT3 antagonists), aprepitant, and dexamethasone. Anticipatory emesis, you use a benzo, and lorazepam is most commonly used.

I think they came out or are coming out with a new combo of NK1 antagonist and 5HT3 antagonist. I forgot what the brand name is. 😕

 

[Kuvan]

yep!

(1) You place a patient that has Hodgkins lymphoma on a chemotherapy regimen consisting of 4 drugs which do NOT have overlapping side effects. One of these drugs causes the patient to have accelerated heart rate and wheezing. Which drug is it? What are the 4 drugs administered?

(2) Later in the clinic you see a patient with non-Hodgkins lymphoma and treat them, again, with a 4 drug chemotherapy regimen. This patient has serious nausea and vomiting before entering the 2nd treatment. Which drug class would be used to treat this condition if it were due to anticipatory emesis? If the patient had high emetic risk following chemotherapy, what would you use to treat it? (Hint: 3 drugs)

Found it! It's called Akynzeo (netupitant and palonosetron) and it's indicated for the prevention of acute and delayed NV. 1 cap (300 mg netupitant/0.5 mg palonosetron) 1 hour prior to the start of chemo. That's it. It's a one dose deal, I guess.

 

[Kuvan]

If you infuse vanco too fast, you can cause what syndrome?
Chloramphenicol can cause what syndrome?
Which are the 2 second generation cephalosporins that cover anaerobes?
Which one from 3rd generation cephalosporins that covers pseudo? How about the one from 4th generation that covers pseudo?

 

[mcloaf]

Which agent is used for bedwetting and can also be used to promote the release of vWF?

Desmopressin.

Which agent for angina that doesn't affect the contractility of the heart or the heart rate?

...Ranolazine?

 

[Kuvan]

Desmopressin.

...Ranolazine?

Ding! Ding! Ding! What's the MOA for ranolazine?

 

[Kuvan]

Which 2 CCBs are safe for pts with LVEF <40%?