EIEC toxins or no

[medman88]

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Hey guys hopefully somebody can confirm this form me. FA says that EIEC produces no toxins, micro made ridic simple and lipincott's say otherwise (that it produces small amounts of SLT - shigella like toxin)

Does anyone know what U world or other sources or does anyone know for sure if it's one or the other.


My bad for posting a bunch of questions like this. It's just incredibly frustrating searching through a bunch of sources only to have them all be divided, so hopefully somebody can help clear this up.

 

[Phloston]

Hey guys hopefully somebody can confirm this form me. FA says that EIEC produces no toxins, micro made ridic simple and lipincott's say otherwise (that it produces small amounts of SLT - shigella like toxin)

Does anyone know what U world or other sources or does anyone know for sure if it's one or the other.


My bad for posting a bunch of questions like this. It's just incredibly frustrating searching through a bunch of sources only to have them all be divided, so hopefully somebody can help clear this up.

As far as I'm aware (and with respect to all USMLE prep I've done so far), EIEC does not produce a toxin. If you see/hear Shiga-like toxin, immediately think EHEC (and only EHEC). The only relation I can think of off the top of my head where EIEC is similar to Shigella is that they both invade the mucosa and induce necrosis.

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The following is all stuff I've picked up from doing loads of practice Qs:

We all know the notable EHEC serotype is O157:H7. If you see O124 --> EIEC.

EAEC = enteroaggregative E. coli --> produces heat-stable toxin (therefore ETEC and EAEC both do) and has both bundle-forming pili and GVVPQ fimbriae.

Why am I highlighting the latter two? Because ETEC uses Type-1 pili to induce travelers' diarrhoea, and 70% of UTIs are due to E.coli utilizing P-pili for epithelial attachment. So at least be able to draw the contrasts.

Rifaximin is a non-systemic antibiotic that stays in the GIT (i.e. not absorbed well) --> great for E. coli.

 

[medman88]

As far as I'm aware (and with respect to all USMLE prep I've done so far), EIEC does not produce a toxin. If you see/hear Shiga-like toxin, immediately think EHEC (and only EHEC). The only relation I can think of off the top of my head where EIEC is similar to Shigella is that they both invade the mucosa and induce necrosis.

-----


The following is all stuff I've picked up from doing loads of practice Qs:

We all know the notable EHEC serotype is O157:H7. If you see O124 --> EIEC.

EAEC = enteroaggregative E. coli --> produces heat-stable toxin (therefore ETEC and EAEC both do) and has both bundle-forming pili and GVVPQ fimbriae.

Why am I highlighting the latter two? Because ETEC uses Type-1 pili to induce travelers' diarrhoea, and 70% of UTIs are due to E.coli utilizing P-pili for epithelial attachment. So at least be able to draw the contrasts.

Rifaximin is a non-systemic antibiotic that stays in the GIT (i.e. not absorbed well) --> great for E. coli.

Nice info thanks! Just wondering where did you pick up all that stuff (i.e. 0124 etc)

 

[Phloston]

Kaplan QBook

I actually also had an exam during MS1 that asked about P-pili. I was surprised this showed up in Kaplan, but I had remembered it somehow.

 

[tigre4411]

Actually, EIEC DOES produce toxins, as clarified in the Errata published by First Aid for the 2013 edition.

http://www.firstaidteam.com/wp-content/uploads/2013-FA-Step-1-Errata-130308.pdf

 

[Morsetlis]

Actually, EIEC DOES produce toxins, as clarified in the Errata published by First Aid for the 2013 edition.

http://www.firstaidteam.com/wp-content/uploads/2013-FA-Step-1-Errata-130308.pdf

I think the important thing is that we don't need to know about EIEC's possible toxins and that its pathology is from invasion --> dysentery, fever, and colitis (NOT watery diarrhea and NO LT/ST toxins). They are also non-motile with non-fimbrial adhesins, and humans are the only reservoirs.