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Could you be so kind as to quote the source of that data? It is difficult to come by.
Could you be so kind as to quote the source of that data? It is difficult to come by.
thx Steve...ill be adding that to my K----- slide show tonight.
T
Avinza- SODAs technology. 10% IR / 90% ER
Oxycontin- Dual polymer Matrix 38% IR / 62% ER
Kadian- 100% ER
Methadone- 100% IR with unpredictable plasma half life, predictable 6hr analgesic efficacy half life
so in their studies they found Methadone to be 100% immediate release? Everyone asked me last night about the IR, so i blamed it on you ;-) , and it just didnt sound right.
T
If interesting you mean poorly written....
I take offense in the abstract as well as some of the content.
From the abstract: "Of course, opioids may cause addiction, but the "principle of balance" may justify that "…efforts to address abuse should not interfere with legitimate medical practice and patient care."
" OF COURSE, OPIOIDS MAY CAUSE ADDICTION" This should have been edited out as it is plainly incorrect.
From the article: "A key paper reporting hospital
rates of addiction was taken out of context and widely
used to support an extremely low rate of addiction
(0.03%) (1)."
Clearly referring to Porter and Jick NEJM 1980- This was a letter to the editor consisting of 101 words (11 lines, 1 paragraph). It is the most referenced addiction "article". Please follow this link to see a copy of the entire article. I'm glad she came out on the right side criticizing the letter. Note that this "article" would not wipe the ass of anybody who knows anything about EBM. They had 11,882 patients and none had any addiction problems prior to their survey and 4 developed addiction problems based on the data they collected. It is fair to say that we all believe the incidence of opioid abuse in the general population is 7% (+/-3%).
Other than these 2 key points, the article was adequately written. If anyone is ready to publish, I'll happily tear you a new one before it hits the press.
Hate to resurrect this thread for something slightly off topic, but is this Porter and Jick Letter to the Editor from 1980 the basis of the claim, repeated ad naseum in so many articles, statements, and texts, that that the chance of addiction for opioids is less than 1%?
Here is another link to the article:
http://www.uofapain.med.ualberta.ca/documents/AddictionRareinPatientstreatedwithNarcotics.pdf
Pain Patient Substance Abuse Rates: The Studies
34% abuse rate in chronic pain populationClin J Pain 1997 Jun;13(2):150-5
Prescription opiate abuse is seen in 24-33% of chronic non-cancer pain patients J Gen Intern Med 2002 Mar;17(3):173-9 Use of opioid medications for chronic noncancer pain syndromes in primary care.
Prescription narcotic abuse is seen in 25% of a chronic pain clinic population Pain Physician 2001 July
24% of spinal cord injury patients report abusing prescription abusable drugs Int J Addict 1992 Mar;27(3):301-16
50% of chronic headache patients had abuse of narcotics over a 3 year period."Patients used medications inappropriately, received them from more than one physician, tried to fill prescriptions early, or claimed to lose them and requested more than prescribed. Neurology. 2004;62:1687-1694
32% Substance Abuse Rate in Chronic Pain Patients Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res. 2006 Apr 46:46.
20-60% Substance Abuse and Illicit Drug use rates depending on insurance class (Medicaid was 60%) J Ky Med Assoc. 2005 Feb;103(2):55-62
24% of patients being treated for chronic low back pain (Ann. Intern. Med. 2007 Jan 16;146(2):116-27)
the only pain patients who i consider ever close to being undertreated are terminal cancer patients - especially those with bone disease
all those other chronic pain patients aren't undertreated from my point of view - they have just "failed" treatment... if you have chronic pain and everything has been tried, and vicodin BID gives you significant relief and your function improves with minimal to no side-effects then great - if you are on oxycontin 80 TID and still feel pain, then therefore you aren't undertreated - you are just not narcotic-responsive... treatment: wean off oxycontin.
it is amazing how many times i see those "chemical copers" who are on oxycontin 80 TID for the treatment of a 20yr hx of chronic daily headaches who swear that they need an increase because it doesn't give them any relief whatsoever... My first comment: "if it isn't giving you any relief then we should discontinue it" - their classic response is "oh, but it does give me relief" - then i respond "that's not what you said a minute ago" - then they blankly stare at me (realizing that they are going to have to perform a bit better)... then they say "it lets me function"... then i ask "why do you think this ridiculous amount of narcotic needs to be increased" ... response: "i still have pain".... then i point out that this is obviously not a treatment that is working for them... then they point out that I am under-treating them... then i point out that their PCP is over-treating them with a medication that doesn't appear to work... then they either listen to me and follow my instructions or they leave.
do cardiologists who refuse to escalate metoprolol beyond 200mg daily undertreat their BP patients? i don't think so...
under-treatment is way over-used when it comes to narcotics and in my opinion it represents the fixation by some chronic pain patients (and the narcotic drug industry) that if they don't get specifically an increase in narcotics they are being under-treated... some are offended that i would consider adding an NSAID or Neurontin or a TENS unit. I guess they went to medical school and are boarded in pain management...
Does anyone have any more information on this nonsense so that we can notify the Texas Board of Medical Licensure?
gorback
in a non-terminal patient who has severe pain the end-point of treatment is opioid-tolerance
http://javascript<b></b>:AL_get(this, 'jour', 'J Pain.'); Steps need to be taken to reduce prescription drug abuse, but very great care needs to be exercised in the nature of these actions so the legitimate and appropriate use of these drugs in the treatment of pain is not compromised as a result.