endocannabinoids

[TinySeahorse]

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I am reading about the body's endocannabinoid system. One source states that endocannabinoids are produced in the mammillary bodies. I cannot find anything else that supports this. Are endocannabinoids hormones, neurotransmitters, or both? If they are not produced in the mammillary bodies, then where are they produced?

Additionally, they are lipophilic. Why, then, do they need cell surface receptors?

This is a serious question. I am an aspiring physician hoping to learn about this hot topic right now so that I understand it for the future. I am trying to understand as much as I can, and I figured these should be easy questions to answer for those with more knowledge.

Tried to post this question in the pharmacy forum but they acted like they had no idea what I was talking about. Kinda sad for people who should know about these things.

 

[SSdoc33]

I am reading about the body's endocannabinoid system. One source states that endocannabinoids are produced in the mammillary bodies. I cannot find anything else that supports this. Are endocannabinoids hormones, neurotransmitters, or both? If they are not produced in the mammillary bodies, then where are they produced?

Additionally, they are lipophilic. Why, then, do they need cell surface receptors?

This is a serious question. I am an aspiring physician hoping to learn about this hot topic right now so that I understand it for the future. I am trying to understand as much as I can, and I figured these should be easy questions to answer for those with more knowledge.

Tried to post this question in the pharmacy forum but they acted like they had no idea what I was talking about. Kinda sad for people who should know about these things.

endocannabinoids are produced in the interstitial glomerula of the hypatian rodullary ducts. they are both lipophilic as well as phobic which is why they can act on both the CNS by crossing the blood brain barrier as well as in the periphery. they use the cell surface receptors outside of the CNS. also, the receptors get modulated by the IL-3 NK cells with CD4+ macrophages when the complement system is activated, but by TNF-6 when its not. pretty basic stuff, actually.....

 

[TinySeahorse]

endocannabinoids are produced in the interstitial glomerula of the hypatian rodullary ducts. they are both lipophilic as well as phobic which is why they can act on both the CNS by crossing the blood brain barrier as well as in the periphery. they use the cell surface receptors outside of the CNS. also, the receptors get modulated by the IL-3 NK cells with CD4+ macrophages when the complement system is activated, but by TNF-6 when its not. pretty basic stuff, actually.....

Are you being sarcastic?? Haha I am a pre-med, still learning. Thanks for the reply! I will read up on this. Someone in the pharmacy forum gave me some nuggets as well.

 

[SSdoc33]

Are you being sarcastic?? Haha I am a pre-med, still learning. Thanks for the reply! I will read up on this. Someone in the pharmacy forum gave me some nuggets as well.

the problem with online conversations is that it is hard to know whether a person is being sarcastic or not. before i went into medicine, i got a PHD in immunology, so this is all spot on. i'd recommend Immunolgy 8th edition by Male et al. as a good starting point. Its a bit remedial, but should meet your needs

 

[clubdeac]

the problem with online conversations is that it is hard to know whether a person is being sarcastic or not. before i went into medicine, i got a PHD in immunology, so this is all spot on. i'd recommend Immunolgy 8th edition by Male et al. as a good starting point. Its a bit remedial, but should meet your needs

ssdoc that was rich....love it

 

[MaximusD]

endocannabinoids are produced in the interstitial glomerula of the hypatian rodullary ducts. they are both lipophilic as well as phobic which is why they can act on both the CNS by crossing the blood brain barrier as well as in the periphery. they use the cell surface receptors outside of the CNS. also, the receptors get modulated by the IL-3 NK cells with CD4+ macrophages when the complement system is activated, but by TNF-6 when its not. pretty basic stuff, actually.....

🙄

 

[TankTuck]

I cannot give you specifics, but I read an article on endocannabinoids years ago. It stated that they act as a regulatory signal on the post-synaptic junction. For example, as the neurotransmitter reaches its receptor on the postsynaptic membrane, changes take place on the membrane releasing/splicing the endocannabinoids from the membrane. These travel retrograde across the synapse and stimulate receptors on the presynaptic membrane (I'm confused too as to why a lipophillic messenger has a cell membrane receptor), somewhat inhibiting the activated presynaptic neuron. The more signal that reaches the postsynaptic receptor, the more endocannabinoids are released. Somewhat of a negative feedback system. I have less of an idea of how they act peripherally, but I believe they have similar effects as endorphin's, producing a state of comfort or euphoria after strenuous situations or exercise.

 

[drusso]

Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. - PubMed - NCBI

Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans.
Fuss J, et al. J Sex Med. 2017.
Show full citation
Abstract
BACKGROUND: Endocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists on rodent sexual activity. However, the involvement of endocannabinoids in human sexual behavior has not been studied.

AIM: To investigate plasma endocannabinoid levels before and after masturbation in healthy male and female volunteers.

OUTCOMES: Plasma levels of the endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide, the endocannabinoid-like lipids oleoyl ethanolamide and palmitoyl ethanolamide, arachidonic acid, and cortisol before and after masturbation to orgasm.

METHODS: In study 1, endocannabinoid and cortisol levels were measured before and after masturbation to orgasm. In study 2, masturbation to orgasm was compared with a control condition using a single-blinded, randomized, 2-session crossover design.

RESULTS: In study 1, masturbation to orgasm significantly increased plasma levels of the endocannabinoid 2-AG, whereas anandamide, oleoyl ethanolamide, palmitoyl ethanolamide, arachidonic acid, and cortisol levels were not altered. In study 2, only masturbation to orgasm, not the control condition, led to a significant increase in 2-AG levels. Interestingly, we also found a significant increase of oleoyl ethanolamide after masturbation to orgasm in study 2.

CLINICAL TRANSLATION: Endocannabinoids might play an important role in the sexual response cycle, leading to possible implications for the understanding and treatment of sexual dysfunctions.

STRENGTHS AND LIMITATIONS: We found an increase of 2-AG through masturbation to orgasm in 2 studies including a single-blinded randomized design. The exact role of endocannabinoid release as part of the sexual response cycle and the biological significance of the finding should be studied further. Cannabis and other drug use and the attainment of orgasm were self-reported in the present study.

CONCLUSION: Our data indicate that the endocannabinoid 2-AG is involved in the human sexual response cycle and we hypothesize that 2-AG release plays a role in the rewarding consequences of sexual arousal and orgasm. Fuss J, Bindila L, Wiedemann K, et al. Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. J Sex Med 2017;14:1372-1379.

Copyright © 2017 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
PMID
29110806 [PubMed - in process]

 

[SSdoc33]

Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. - PubMed - NCBI


METHODS: In study 1, endocannabinoid and cortisol levels were measured before and after masturbation to orgasm. In study 2, masturbation to orgasm was compared with a control condition using a single-blinded, randomized, 2-session crossover design.

29110806 [PubMed - in process]

i didnt pull the article up, i wonder what this was all about. did they just let you watch the porn but not touch yourself?