Eosinophils

[Qester]

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Hello,

I was hoping someone could help me understand eosinophils and their role in disease. I have a few questions pertaining to them.

I originally thought of eosinophils of anti-helminth and a 'clean up crew' being attracted to the area of a type 1 hypersensitivity by eosinophilic chemotactic factor and then releasing histaminase to clean up the mast cells mess (also explaining why there is eosinophilia in asthma and allergic reactions).

However I just had a question that stated eosinophils release histamine in the explanation, which I haven't been able to confirm and hadn't seen before, does anyone know about this?

Also I know that both mast cells and basophils interact with IgE. Do Eosinophils have any interaction as well?

Thank you

 

[Reperfused]

What's the source of the question?
If it's anything other than UWorld then I wouldn't worry about it. I had the same concept like you that eosinophils secrete histaminase and aryl sulfatase.

However, if it's uworld, then it's a problem!

 

[DerpStore]

Hello,

I was hoping someone could help me understand eosinophils and their role in disease. I have a few questions pertaining to them.

I originally thought of eosinophils of anti-helminth and a 'clean up crew' being attracted to the area of a type 1 hypersensitivity by eosinophilic chemotactic factor and then releasing histaminase to clean up the mast cells mess (also explaining why there is eosinophilia in asthma and allergic reactions).

However I just had a question that stated eosinophils release histamine in the explanation, which I haven't been able to confirm and hadn't seen before, does anyone know about this?

Also I know that both mast cells and basophils interact with IgE. Do Eosinophils have any interaction as well?

Thank you

Yes eosinophils express the fceri receptor for IgE and can release major basic protein etc upon crosslinking. They classically do not secrete histamine.

 

[Reperfused]

Hello,

I was hoping someone could help me understand eosinophils and their role in disease. I have a few questions pertaining to them.

I originally thought of eosinophils of anti-helminth and a 'clean up crew' being attracted to the area of a type 1 hypersensitivity by eosinophilic chemotactic factor and then releasing histaminase to clean up the mast cells mess (also explaining why there is eosinophilia in asthma and allergic reactions).

However I just had a question that stated eosinophils release histamine in the explanation, which I haven't been able to confirm and hadn't seen before, does anyone know about this?

Also I know that both mast cells and basophils interact with IgE. Do Eosinophils have any interaction as well?

Thank you

You sure you didn't misinterpret the question?
Eosinophils secrete major basic protein which causes the release of histamine from mast cells and basophils.
Maybe the qs explanation was trying to say something along these lines?

 

[Qester]

You sure you didn't misinterpret the question?
Eosinophils secrete major basic protein which causes the release of histamine from mast cells and basophils.
Maybe the qs explanation was trying to say something along these lines?

I could be wrong, but I thought histamine from mast cells and basophils was due to cross linking of IgE bound Fc receptors, not major basic protein. Upon cross linking mast cells release histamine and eosinophil chemotactic factor, which then brings in eosinophils.

Its an Rx question and in the explanation it says "Eosinophils release [...] histamine"

 

[Reperfused]

Hmmm ok.
Even I'm doing RX these days. Could you please share the QID?
Let me tell you my opinion, although I'm loving RX in the sense that it's the best way to go through FA, but I believe it has a fair share of mistakes in the explanations. So if there's contradicting statements from other more authentic sources, or weird concepts that you haven't come across elsewhere and you feel they're wrong, they probably are!

And 'eosinophils producing histamine' does sound like one of those weird/wrong concepts.

That's how I go about it.

 

[Transposony]

However I just had a question that stated eosinophils release histamine in the explanation, which I haven't been able to confirm and hadn't seen before, does anyone know about this?

Also I know that both mast cells and basophils interact with IgE. Do Eosinophils have any interaction as well?

Thank you

Not sure if eosinophils release histamine but they do interact with IgE coated parasites via CD16.

 

[Qester]

Hmmm ok.
Even I'm doing RX these days. Could you please share the QID?
Let me tell you my opinion, although I'm loving RX in the sense that it's the best way to go through FA, but I believe it has a fair share of mistakes in the explanations. So if there's contradicting statements from other more authentic sources, or weird concepts that you haven't come across elsewhere and you feel they're wrong, they probably are!

And 'eosinophils producing histamine' does sound like one of those weird/wrong concepts.

That's how I go about it.

QID 3070

 

[Reperfused]

Opsss... Just realized I don't know how to search for a qs using a QID. I tried to look but couldn't find how to search.
Can someone help please?