errors in FA 2007

[viostorm]

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I suggest we post any errors we find in FA 2007 here.

I'll start:

P. 106 - Deficient enzyme on Von Gierke's disease is Glucose-6-phosphotase not glucose-6-phosphate.

 

[microTAS]

Here we go! my list is only up to half-way page 2 and i added 1 more...

*94: glucose-1-phosphate <-> glucose-6-phosphate (see p.105)

*96: switch arrows on reg by f2,6bp

98: increase in permeability

*105: (1) cat. udp-glucose

*106: glucose-6-phosphat(+ase)

*117: CPK = CK

*125: switch dark and light colors on first table

*145: O157:H7 = EHEC

*163: CXCR1 -> CXCR4

*194: Hashimoto's thyroiditis also type II

*223: Quinidine is inhibitor

*391: interlobular a/v -> arcuate a/v

*400: SLE: diffuse proliferative form is prototype and has subendo deposits

*450: newborns w/ meningitis => Grp B Strep also

 

[Prop]

P. 92 - Collagen synthesis and structure.

This one is kind of difficult, but completely wrong in FA. Glycosylation, and formation of triple helix collagen occurs inside RER, NOT inside the Golgi complex!
I've made a new "list" to remove all the errors:

Inside fibroblasts:
1) Synthesis of preprocollagen inside RER
2) Hydroxylation of specific proline and lysine residues inside RER
3) Glycosylation of hydroxylysine and lysine inside RER
4) Formation of triple helix procollagen from 3 collagen alpha-chains inside RER
5) Addition of carbohydrates inside Golgi complex
6) Secretion of procollagen

Outside fibroblasts:
1) Cleavage of procollagen to form tropocollagen
2) Self-assembly of tropocollagen into fibrils
3) Cross-linking of tropocollagen to make collagen fibrils

 

[nne97080]

On page 394, under E. Collecting Tubules, the pic shows a Na/H ATPase antiporter. The pic it's taken from in Katzung shows the ATPase as only secreting protons (no sodium involved).

I thought FA was correct in this aspect. I dont get ur correction here ??

 

[TheEleventhReel]

I thought FA was correct in this aspect. I dont get ur correction here ??

The correction is that the transporter is a H+/ATPase, not a Na+/H+ ATPase. It was correct in the 2006 version, but incorrect in the 2007 version.

 

[007Dabomb]

Is there a complete list of errors that everyone agrees to available? It would be extremely helpful !!

 

[Teejay]

P165
Now this one freaks me out cuz i've studied this page like this for two months 🙁 . I just got a question wrong in Uworld because of this mistake.
FA says that N.meningitis is the most common cause of bacteria meningitis in people Between 6-60yrs. This margin is wide and unspecific. Strep pneumonia is the most common cause of Bacteria meningitis in people >18yr and N. meningitis is the most common for 1month-18yrs. However, N.meningitis is the second most common cause in patients <60yr. My sources are Goljan RR and Uworld.

 

[Taus]

P165
Now this one freaks me out cuz i've studied this page like this for two months 🙁 . I just got a question wrong in Uworld because of this mistake.
FA says that N.meningitis is the most common cause of bacteria meningitis in people Between 6-60yrs. This margin is wide and unspecific. Strep pneumonia is the most common cause of Bacteria meningitis in people >18yr and N. meningitis is the most common for 1month-18yrs. However, N.meningitis is the second most common cause in patients <60yr. My sources are Goljan RR and Uworld.

did a question really require you to know what was most common in an age group to get an answer?....I would assume that a legit question would require you to make the dx based some other factors in the stem beyond what is the most common (and that the age would only narrow down your choices)

 

[Teejay]

did a question really require you to know what was most common in an age group to get an answer?....I would assume that a legit question would require you to make the dx based some other factors in the stem beyond what is the most common (and that the age would only narrow down your choices)

The answer to the question could only be inferred from the age of the patient and the morphology of the bacteria because the clinical presentation for both is virtually the same. The answer chioces had both N meningitis and strep pneumonia structural morphology(bean shaped and lancet shaped), so you had to know it. The question stem also said the patient was an adult.

 

[Teejay]

duoble post.

 

[goodies]

page 278 portal-systemic anastomoses. do you get EXTERNAL hemorrhoids or internal hemorrhoids from superior--> inferior rectal veins with portal hypertension?

FA says external, Kaplan anatomy says internal. which is it?

 

[LauraMac]

p. 224 says st. john's wort inhibits the p-450 system, when it actually induces it. somehow it's correct on the previous page.

 

[pleaseletmepass]

page 326, top, on smooth muscle contraction:
Where the arrow of Myosin + actin points, "contraction" should be changed to "relaxation"

 

[Taus]

not sure if this is an error or I'm just thinking about it the wrong way...

P. 405 under Mannitol...it says it increases tubular fluid osmolarity

I just don't see how thats possible b/c I know it prevents the re-absorption of water and assume that would dilute whatever was in the tubules....what am I missing?

 

[blz]

not sure if this is an error or I'm just thinking about it the wrong way...

P. 405 under Mannitol...it says it increases tubular fluid osmolarity

I just don't see how thats possible b/c I know it prevents the re-absorption of water and assume that would dilute whatever was in the tubules....what am I missing?

the increased tubular osmolarity is what prevents the water reabsorption (the increased osm in the tubule due to the mannitol osmotically pulling in water). this is the same way that glucosuria causes polyuria in diabetes.

I think maybe you're paying more attention to the final result of mannitol rather than the direct effect of mannitol.

 

[Taus]

the increased tubular osmolarity is what prevents the water reabsorption (the increased osm in the tubule due to the mannitol osmotically pulling in water). this is the same way that glucosuria causes polyuria in diabetes.

I think maybe you're paying more attention to the final result of mannitol rather than the direct effect of mannitol.

ohhhh...got it..thanks

 

[acl3623]

P. 410 - bottom drawing on sperm development.
Spermatogonium don't go through mitosis to become primary spermatocytes- they enter meiosis I, undergo DNA replication to become primary spermatocytes (4N)--> primary spermatocytes complete meiosis 1 to form secondary spermatocytes (2N)--> meiosis II--> spermatid (N)

However, spermatogonium do undergo mitosis to produce a continuous supply of stem cells that last males their entire reproductive life.

 

[acl3623]

now this one i've found some conflicting info...
p. 191 classic pathway C2 is cleaved into 2a and 2b, FA shows that C2b attaches to C4b making C3 convertase

However, BRS immuno says that C2 is cleaved and C2a attaches with C4b (making C3 convertase), and that C2b is released in the fluid phase and acts like a kinin.

I googled...Wiki has a picture that was supposedly taken from an NIH document that shows C2a as part of C3 convertase..I also have that in my own notes. But there are a few other sites that show C2b as the component. I dont have an immuno text...anyone know which C2 it really is?

 

[TheEleventhReel]

now this one i've found some conflicting info...
p. 191 classic pathway C2 is cleaved into 2a and 2b, FA shows that C2b attaches to C4b making C3 convertase

However, BRS immuno says that C2 is cleaved and C2a attaches with C4b (making C3 convertase), and that C2b is released in the fluid phase and acts like a kinin.

I googled...Wiki has a picture that was supposedly taken from an NIH document that shows C2a as part of C3 convertase..I also have that in my own notes. But there are a few other sites that show C2b as the component. I dont have an immuno text...anyone know which C2 it really is?

We learned that it doesn't matter if it's C2aC4b, C2bC4b, or whatever. We were told that the importance is that you need 1 mlc of C2 and 1 mlc of C4 to make the C3 convertase.

 

[blz]

I noticed this too while reading HY Immuno. It shows 2a in the C3 convertase. I highly doubt this point is a big deal.

 

[drbetty]

schistosoma - say that 10x fast!

anyway, FA conflicts w/BRS path (pg 270), Goljan, and emedicine (http://www.emedicine.com/MED/topic2344.htm)

• pg 401 Transitional cell carcinoma of the badder is associated with problems of your Pee SACS

• drop the last S for Schistosoma because, Schisotoma Haematobium is associated with squamous cell cancer of the bladder

 

[guitarguy09]

Here is an "official" correction list...

http://usmlerx.wordpress.com/first-aid-corrections/

Good luck everyone. Peace.

 

[blz]

Here we go! my list is only up to half-way page 2 and i added 1 more...

*94: glucose-1-phosphate <-> glucose-6-phosphate (see p.105)

*96: switch arrows on reg by f2,6bp

98: increase in permeability

*105: (1) cat. udp-glucose

*106: glucose-6-phosphat(+ase)

*117: CPK = CK

*125: switch dark and light colors on first table

*145: O157:H7 = EHEC

*163: CXCR1 -> CXCR4

*194: Hashimoto's thyroiditis also type II

*223: Quinidine is inhibitor

*391: interlobular a/v -> arcuate a/v

*400: SLE: diffuse proliferative form is prototype and has subendo deposits

*450: newborns w/ meningitis => Grp B Strep also

pg 163 CXCR1 is correct as written. mutation associated with increased progression of the disease

 

[sierra89]

p. 313 - For CML it reads "myeloid stem cell proliferation" but Robbins says pluripotent stem cell is affected in CML (p. 696)

I don't know if first aid is specifically referring to which type of stem cell has the (9,22) translocation, or if it is referring to seeing myeloid cells in bone marrow biopsy?

 

[bugger]

page 216----pyridostigmine doesn't cross BBB

FA says it does cross, which is wrong.

 

[amy2003uva]

edit

 

[g.badran]

This is the official page of FA errors:
http://usmlerx.files.wordpress.com/2007/05/first-aid-step-1-updates-may-2007-rx.pdf

 

[bugger]

pg 185----says that MHC Class II are major determinants of organ rejection....both BRS Path and Goljan RR, say MHC Class I are the major determinants.

 

[HunterGatherer]

Well looks like the publishers started a website where they update the errata each month. There is a page for their other books as well. If you used the PDf file from May 2007 you just need to look at the months including June 2007 and forward.

This page should show updates by month. FA USMLE Step 1 2007 page:
http://firstaidteam.com/category/step-1/

main errata page for 3 of the books (FA Q&A Step 1) they offer:
http://firstaidteam.com/updates-and-corrections/

FA 2007 PDF last updated May 2005 (as shown in previous post)
http://usmlerx.files.wordpress.com/2007/05/first-aid-step-1-updates-may-2007-rx.pdf

If you have not made any corrections this is all the errata combined to date (as of today):
http://firstaidteam.com/updates-and-corrections/usmle-step-1/

wonder if they will take down the 2007 errata when 2008 comes out. They did this for the 2006 errata. 🙄