You can make almost anything translational research- you just have to start with a patient centered question and take it down to a more physiologic level. Tons of good examples in almost any discipline:
Example from peds from a few years ago- antibiotics for pedi ear infections?? answer: study what causes them =60%+ virus- so no.
1 study- swab kids ears and there you go.
or HIV- diabetes treatment for antiretroviral lipodystrophy and associated insulin resitance? You see the problem in the patient and try to take it to the cellular molecular level - so hwat is the abnormaility in fat metabolism induced by those drugs?
Theoretically not nearly as hard as you think, just requires a lot of varied skill sets.....
don't let the fancy name scare you!!