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pox....for you and anyone else
inc vit D (excess intake)--> increased Ca abs (intestinal/kidney absorption)
--> Decreased PTH (2ndary Hypoparathyrodism)--> increased phosphate;
couple of possibilities...
1) Over time increased phosphate may infact stimulate an increase in PTH--> there by allow dumping of the phosphate; PTH can stimulate osteoclast activities and cause OP
2) The vit D + PTH combo is required for Vit D to induce bone reportion (via osteblast signal to osteoclasts). Even though PTH may decrease, it doesn't go to zero.....so the Vit D + PTH can stimulate resorption
3) Increased phosphate may actually bind Ca2+ and prevent bone deposition and thereby lead to decreased bone mass over time. This may be the mechanism for "soft drinked" induced osteoporosis. With soft drinks, the increased phosphate in the digestive tract may make it more difficult for Ca2+ to be absorbed.
hope this helps
ucb
inc vit D (excess intake)--> increased Ca abs (intestinal/kidney absorption)
--> Decreased PTH (2ndary Hypoparathyrodism)--> increased phosphate;
couple of possibilities...
1) Over time increased phosphate may infact stimulate an increase in PTH--> there by allow dumping of the phosphate; PTH can stimulate osteoclast activities and cause OP
2) The vit D + PTH combo is required for Vit D to induce bone reportion (via osteblast signal to osteoclasts). Even though PTH may decrease, it doesn't go to zero.....so the Vit D + PTH can stimulate resorption
3) Increased phosphate may actually bind Ca2+ and prevent bone deposition and thereby lead to decreased bone mass over time. This may be the mechanism for "soft drinked" induced osteoporosis. With soft drinks, the increased phosphate in the digestive tract may make it more difficult for Ca2+ to be absorbed.
hope this helps
ucb
