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FA Leydig cell tumor

Discussion in 'Step I' started by agranulocytosis, Jun 13, 2008.

  1. agranulocytosis

    Physician 10+ Year Member

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    page 452 2008, Leydig cell tumors produce gynecomastia in men. What say you guys?
     
  2. boardssuck

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    i think the excess androgens get aromatized
     
  3. osli

    osli Senior Member
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    Leydig cell tumors can be stimulated (perhaps even started) by excess estrogen and/or LH (usually from HPA dysfunction), so there may be an association there in some cases even though cause/effect is reversed.

    Additionally, even though most produce testosterone some can intrinsically produce progesterone and/or estradiol. Finally, increases in estrogen can occur from peripheral aromatization of the excess testosterone in obese individuals, though I would think that is the least likely scenario to produce new gynecomastia observed in combination with the tumor's appearance.
     
  4. agranulocytosis

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    awesome, nice answers guys!
     

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