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Polyps arise in the colon of a FAP pt around puberty. Why does it specifically take place around puberty ? Hormonal influence ?
FAP and Puberty
- Thread starter kagman
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Source: http://emedicine.medscape.com/article/175377-overview#a5
My take on it: People with classic FAP have 1 mutated APC allele in every colonic cell. Thus if the remaining allele were to be inactivated in a single cell by a sporadic mutation or a deletion for example, they would go on to develop adenomatous polyps. There is a very high probability that inactivation (mutation, deletion) of the remaining allele in at least one of those cells occurs by puberty.
My take on it: People with classic FAP have 1 mutated APC allele in every colonic cell. Thus if the remaining allele were to be inactivated in a single cell by a sporadic mutation or a deletion for example, they would go on to develop adenomatous polyps. There is a very high probability that inactivation (mutation, deletion) of the remaining allele in at least one of those cells occurs by puberty.
