Good morning gentlemen,
Just walked into call today, no cases on the list yet, so here goes:
Regards to my seeming propensity for gas in spite of my name, I actually am extremely fond of total intravenous anesthetics because of their smooth emergences and euphoric wake ups. I truly believe anesthesia is an art and I hate the emergences with gas. At least in my hands, I have difficulty facilitating smooth and rapid wake ups, it's either one or the other, not both. But with TIVA, I can in fact more easily accomplish those two goals. Plus, I don't have to worry about the blunting of hypoxic vasoconstriction, but I'll talk about that later.
There was a thread not too long ago called "Des wake ups." For those who doubt my fondness of intravenous techniques, if you peruse that thread, you will find post #20 championing TIVA.
However, there are a studies that show significantly higher troponin levels (both statistically and clinically) post cardiac surgery with TIVA as opposed to with volatiles. I will post the names of the articles in the near future. And I cannot find one anesthesiologist who will agree to do cardiac surgery without the use of volatiles. Why? Because studies (also to be provided in the near future) show that volatiles potentiate ischemic preconditioning -- thereby lowering infarct size, improving EF, and reducing ventricular arrhythmias.
So, if you're willing to believe the cardiac anesthesia literature, which I am, then if volatiles are good for patients with heart disease undergoing heart surgery, then those very same volatiles are probably good for patients with heart disease undergoing non cardiac surgery.
Can I fault anyone for not choosing a volatile over another anesthetic plan such as spinal or regional block? Absolutely not. It depends on the individual, their comorbidities, the anesthesiologist, and the surgery they're about to have. But given the case that Trinity presented, with all the info he gave on his dad-in-law and all the comorbidities he has, then I feel a pre-op epidural (tested, not dosed), GA with volatile and intraop fentanyl would be good. Can a spinal or epidural or regional technique get the person through a TKA safely? Sure. But consider the following ...
Which brings me to the topic of hypoxic vasoconstriction and the obliteration of that effect by volatiles.
Yes, volatiles do blunt this effect. But in someone with pre-existing lung disease, be it restrictive (which the dad-in-law has with pulm fibrosis) or obstructive (such as with COPD), their lungs are resistant to this effect. Yes, let me repeat that ... Volatiles are not able to blunt the hypoxic vasoconstriction of pulmonary vasculature in sick lungs as compared to healthy lungs. Why? Because sick lungs, with all there intrapulmonary shunts and increased vascular thickening lead directly to pulmonary hypertension. PH is resistant to volatile-related blunting of hypoxic vasoconstriction, which works to our advantage in the OR cuz then we're not chasing the cause of low sats or what have you. In fact, have you not noticed this in your own patient population? COPD'ers satting 100% all day long on less than 40% O2.
Oh, yeah, also, the problem with spinals in CAD patients is that you have to keep a very, very close eye on their diastolic pressure lest you drop their coronary perfusion pressure. So I agree with the neo drip being nearby. And you also have to keep a close eye on MAP's cuz in a vasculopath, the heart and the kidneys love pressure. Remember, we are perioperative physicians, not just sleep doctors.
Anyways, moving on ...
With regards to PFT's? Agree with those who say "nah."
With regards to what to do with that additional info that further cardiac eval will provide? Now that is probably the heart of the issue (no pun intended ... well, okay, intended). Excellent point. Would the father-in-law be a candidate for PCI or redo bypass?
Let's say the stress test shows something minor or stupid like possible inferior attenuation ... then no, no further workup warranted. But if there is a significant reversible perfusion deficit (such as moderate size, moderate area in territory of LAD, or a significant reversible wall motion abnormality), then if I was the patient, I think I would be interested in knowing that information ... some potentially life threatening, rate-limiting flow lesion vs blindly going into a totally elective procedure that requires me to withhold my aspirin which is keeping that one platelet from unleashing that pack of ravaging wolves in an unstable plaque. I think I would want to know, if I were the patient.
We as anesthesiologists are not the patient's primary care doctor. But we are more than technicians in some assembly line that just put patients to sleep and keep them from moving under the surgeon's knife. We teeter them along on the line between not feeling pain ... and death. For those who are healthy, that line is broad. For those who are not, that line is thin.
So, in Trinity's case, I think at the very minimum a chemical stress test is warranted. After all, as someone mentioned previously, the life of graft patency is about 10 years and the father-in-law is 15 years post CABG.
Which stress test? According to my cardiology buddy, if you want it to be positive, go with the adenosine thallium, if you want it to be negative, go with the dobutatmine stress echo.