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Dogs and cats seem to tolerate chemo much better than humans and most of the chemo rechecks that I've seen so far have very little side effects (maybe 1 in every 5 patients will have vomiting/diarrhea).
This. The point of chemo in pets is not to try and beat cancer by all means possible. It's to prolong good quality of life as long as possible, whether that means complete remission or not. It's a very personal decision for the owners to decide if the finances and multiple trip to the oncologists is worth it for the 1, 2, 6, 9, 12+ months of extra time they have with their pet. Some say yes, many many will say no, but neither is wrong.
For very chemo responsive cancers like lymphoma, I always always offer chemo as some of those pets can live years often to the tune of something else killing them first. It's a little tedious, it's expensive, and it's not certainly for everyone, but the people who take their pets for treatment being fully informed are usually very very glad. I make sure they are fully aware so that they don't end up in the, "I spent $5000 on my dog for cancer and she died 8 months later. I would never do it again" camp.
I've had a few takers on splenectomy for bleeding mass that turned out (shockingly) to be HSA. The owners were made fully aware that that was more the rule than the exception and what a grave diagnosis that would be. They lived excellent quality of life until they sharply declined 6 months later and the owners were grateful of the time they got with their pet. They knew full well that the dog could die on the table, in the post op period, or get sick from mets very quickly.
I currently have a young dog with osteosarc who went through radical resection and is following through with chemo, living the life. Have had to delay chemo a couple times due to low white cell count, but the dog has not had a single bad day since maybe 1 week after the operation. It's been gosh, maybe 5 months now, and she is as happy as she has always been. The owners are cautiously optimistic and ready for the other shoe to drop any minute, but they are super glad with the decision they made.
I also have an old dog who came in to me circling the drain in shock a few days after a totally unrelated anesthetic procedure. Like, had a BP of 40... with a temp so low out thermometer wouldn't read. Owner didn't blame me for it at all, and consented for me to revive him. He responded well and was stable when I shipped him to another facility 20 min away. During the transport, he crashed again. Turned out to be a bleeding tumor in the lungs. Owners consented to pup being revived again rather than putting him down, and he went home. I'm amazed every time a med refill request is in for that dog. It's also been 5+ months with him. He's on vit k and yunan baiyao, no chemo. The owner took him home so that his grown kids could all come home and say goodbye.
While there are plenty of other cases where if I didn't euthanize the animal shortly after diagnosis even with Cadillac treatment, I'm sure outcome would not have been fab. But I'm amazed all the time by how well many of these pets do when given the chance. So for that reason, I don't discourage it. I make sure the owners are fully informed, but I am not the one to say, well your dog has cancer so we should stop, or make it sound like chemo is this out of the world thing that only crazy people go for, or that chemo is a selfish decision for the owner. The second the owner says it's not their thing, I fully support them with their end of life decisions and never question it, but I have them make it.