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For the question about greatest personal weakness, would something like "My greatest weakness is that I have trouble connecting with people." be an appropriate response, if I was able to talk about what I've done to improve it and demonstrate that improvement via a (hopefully) successful interview? Or would simply mentioning it leave them subconsciously evaluating me for signs of discomfort or social awkwardness?
They'd be consciously evaluating you for signs of discomfort and social awkwardness. I'm not sure exactly what you mean by "trouble connecting with people" but it sounds as if you lack (a) empathy or (b) social skills or (c) all of the above. Those aren't exactly qualities you'd want in a physician, regardless of how far you've come since you started correcting the problem(s).