Genetics question

[BodybldgDoc]

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Is the DNA strand(3' to 5' sequence) that serves as a template for the synthesis of a complementary strand of mRNA called the sense strand or anti-sense strand?

 

[DentalKitty]

*Edit* I was wrong, need to study more I guess 🙂

"Sense strand is the strand of DNA during transcription which is not transcribed into mRNA. This is because it is colinear as opposed to complementary for the RNA sequence. It makes "sense" with the genetic code."

Template = Anti Sense

 

[BodybldgDoc]

*Edit* I was wrong, need to study more I guess 🙂

"Sense strand is the strand of DNA during transcription which is not transcribed into mRNA. This is because it is colinear as opposed to complementary for the RNA sequence. It makes "sense" with the genetic code."

Template = Anti Sense

ahh ok. Then I guess I was right. I have an AP Bio book that says the template to the mRNA strand is called the sense strand. thanks dental kitty

 

[BodybldgDoc]

Btw Lonely Sol Guru of all Bio. Can you please confirm if this correct? thanks buddy.

 

[Lonely Sol]

Is the DNA strand(3' to 5' sequence) that serves as a template for the synthesis of a complementary strand of mRNA called the sense strand or anti-sense strand?

Yea buddy, you are right, it is Anti-strand; here is an explanation if you need:

Let say DNA squence is 5p AATTCCGG 3p
Now, the template strand = anti= Nonsense strand is 3p TTAAGGCC 5p
Now the sense stand = 5p AAUUCCGG 3p

Therefore, the reason it is called the sense strand is because when you compare it to the orginal DNA seq (5p-3p), it matches exactly except for T replaced by U.

Nonsense strand is basically as you said, template strand of the original 5p-3p sequence.


Hope this helps!!

 

[xplayer2885]

yesss sirrrr, because the DNA cannot be read simulatianiusly so one side reads something like every other gene. Im pretty sure its the 5 to 3 prime end.

 

[BodybldgDoc]

thank you sol, you know your stuff. Your going to ace the bio section for sure.

 

[DentalKitty]

Yea buddy, you are right, it is Anti-strand; here is an explanation if you need:

Let say DNA squence is 5p AATTCCGG 3p
Now, the template strand = anti= Nonsense strand is 3p TTAAGGCC 5p
Now the sense stand = 5p AAUUCCGG 3p

Therefore, the reason it is called the sense strand is because when you compare it to the orginal DNA seq (5p-3p), it matches exactly except for T replaced by U.

Nonsense strand is basically as you said, template strand of the original 5p-3p sequence.


Hope this helps!!

Lonely Sol, but I thought when they say "sense" or "anti/non-sense" they are referring to DNA, not the RNA transcript. In that case then the sense strand would be the 5' AATTCCGG 3' (DNA) vice the 5' AAUUCCGG 3' (RNA). Is that correct?

 

[jdmsamurai]

1) rule of thumb everything is made from 5' end to 3' end......from DNA synthesis to RNA synthesis

i guess you wondering hows that possible for DNA in its SemiConservative model...
well the leading strand is synthesize continuously from 5' to 3' without interruption while the lagging strand is synthesis discontinously with RNA primer (Okazaki fragments)...

and for all the other people....when you have DNA..and you have strand 1 and strand 2 which are complement of each other..any of the strand during a short segment could be anti-sense for one gene and sense for another.

i hope that makes "sense" hahaha...no pun intended

 

[Lonely Sol]

Lonely Sol, but I thought when they say "sense" or "anti/non-sense" they are referring to DNA, not the RNA transcript. In that case then the sense strand would be the 5' AATTCCGG 3' (DNA) vice the 5' AAUUCCGG 3' (RNA). Is that correct?

Yea I am sorry! got a little carried away there, but you are right, the sense and antisense refer to DNA and not RNA. So the first strand is sense strand (5p-3p) and 2nd one is antisense (3p-5p). But the reason why it is sense is as I explained. Stupid me!🙄

 

[ATLATLATL]

sense-dna template
anti-complimentary strand...

hmmm now that's sensible.....

 

[Lonely Sol]

sense-dna template
anti-complimentary strand...

hmmm now that's sensible.....

Well, no...original DNA sequence is the sense strand (the one running 5-3) and the template strand is the anti-sense strand (the one running 3-5).

 

[jdmsamurai]

sense-dna template
anti-complimentary strand...

hmmm now that's sensible.....

not really....both the sense and antisense strand are "dna templates" for making DNA....

anti-complementary strand huh?! not really again....

when people talk about sense and anti-sense it could be any of the strand as long as its the complementary to the RNA which codes for a gene....

i think people are getting mixed up between DNA replication vs RNA synthesis...