GI bleed --> hyperammonemia

[loveoforganic2]

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Can anyone comment on the pathogenesis of hyperammonemia w/GI bleeds? I can't seem to put it together.

TYIA

 

[Transposony]

Hyperammonemia is due to bacterial degradation of blood (high in protein) into amines, amino acids, purines, and urea. Normally, liver has vast capacity to detoxify ammonia so it only is a problem (hepatic encephalopathy) in pts with liver compromise (cirrhosis) and/or Porto-systemic shunting (TIPSS).

 

[loveoforganic2]

Awesome, thanks a bunch