GLP-1 Meds for Pain, Addiction, Obesity, Neurogenic Inflammation...

[drusso]

Top U.S. addiction researcher calls GLP-1 data for addiction 'very, very exciting'

An addiction expert says drugs like Wegovy are showing exciting results for addiction, but adds that “the pharmaceutical industry has never spontaneously embraced us and said, ‘We want to help develop treatments.’"

www.statnews.com

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[Ferrismonk]

If only any of the GLP-1s could stay in stock.

 

[drusso]

If only any of the GLP-1s could stay in stock.

Compounding pharmacies.

 

[Ducttape]

some people who need it for FDA approved medical treatment are not finding it available or are having insurance price it out of use.

compounding pharmacies are not a solution. remember last time people were recommending compounding injectables? NEC?

 

[BobBarker]

@Ducttape i think a sq injectable isn’t comparable to epidural or intradiscal which was the case with NEC. Apples to oranges.

 

[MitchLevi]

Nevro trial today on a woman with an A1C 7.3, who was 10.9 3 months ago until Monjouro (sp). Huge improvement.

 

[lobelsteve]

Nevro trial today on a woman with an A1C 7.3, who was 10.9 3 months ago until Monjouro (sp). Huge improvement.

Would still use Epifix.

 

[MitchLevi]

If I ‘plant her I will

Would still use Epifix.

 

[pastafan]

Compounding pharmacies.

In this case where are the pharmacies getting the base drugs for compounding? These are all under patent and the manufacturers aren’t sharing.

 

[gaseous_clay]

These drugs are really affecting anesthesia providers. The ASA recs for holding them prior to surgery are best guesses. You should read some of the case reports of patients holding these meds and following NPO guidelines, but they are still evacuating 1+ liters of gastric contents during surgery.

 

[BobBarker]

The guideline is to hold for a week. The half life is 6-7 days. Then you have the person that has been on a high dose for months. So there levels are quite high still after one week and the patient doesn’t even miss a dose by holding a week.

 

[pastafan]

Gastroparesis is a known side effect.

 

[MitchLevi]

Gaatroparesis is one of the reasons it works IMO

 

[gaspasser127]

Would still use Epifix.

What’s Epifix ?

 

[lobelsteve]

What’s Epifix ?

Amniotic tissue extract sheets. A skin graft substitute to augment tissue healing. It goes in the deep wound bed to allow earlier epithelialization and reduce risk of wound infection. Used frequently in cervical cuff surgery for gynecology as well as rotator cuff surgery.

 

[drusso]

Amniotic tissue extract sheets. A skin graft substitute to augment tissue healing. It goes in the deep wound bed to allow earlier epithelialization and reduce risk of wound infection. Used frequently in cervical cuff surgery for gynecology as well as rotator cuff surgery.

Is this regen?

 

[lobelsteve]

Is this regen?

Preventative medicine

 

[DrSwede]

Preventative medicine

So in the context of the SCS implant, where exactly are you putting it? IPG site? Midline pocket for the leads?

 

[Keona]

In this case where are the pharmacies getting the base drugs for compounding? These are all under patent and the manufacturers aren’t sharing.

They apparently aren’t allowed to defend their patent when there’s a shortage of the medication. Only when they’re not on the shortage list can they go after the compounding pharmacies. (That’s one of the drug reps told me at least).

 

[pastafan]

The Truth About Compounded GLP-1s That Doctors Need to Know

Medical societies and the FDA have issued critiques about compounding pharmacies, but Eldad Einav, MD, argues that there are steps that can be taken to ensure patient safety.

www.medscape.com

 

[gaspasser127]

So in the context of the SCS implant, where exactly are you putting it? IPG site? Midline pocket for the leads?

I assume both?

 

[gaseous_clay]

The guideline is to hold for a week. The half life is 6-7 days. Then you have the person that has been on a high dose for months. So there levels are quite high still after one week and the patient doesn’t even miss a dose by holding a week.

Actually ASA’s guidelines are hold for 7 days if dosed weekly, hold day of surgery if dosed daily.

American Society of Anesthesiologists Consensus-Based Guidance on Preoperative Management of Patients (Adults and Children) on Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists

www.asahq.org

 

[BobBarker]

Yes, Liraglutide has a half life of 11-12 hours. Not used very often comparatively. Saxenda/Victoza