Glucose oxidation help!

[sakthivs]

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Ok so If we assume that NADH produces 3 ATP and FADH2 produces 2 ATP, we have:

net 2 ATP (glycolysis)
2 NADH or 6 ATP (glycolysis)
2 NADH or 6 ATP (pdh reaction)
6NADH or 18 ATP (krebs)
2FADH2 or 4 ATP (krebs)
2 GTP/ATP (krebs)

so this is where the 38 ATP comes from. But do we also account for the shuttling of NADH from the cytoplasm into the mitochondria. That would be -2 ATP so finally a net of 36 ATP. But doesn't it also cost ATP to move pyruvate into the mitochondria to start the PDH complex reaction? so would that be another -2 ATP? I am so confused because different sources have different yields for ATP.

 

[imrandom]

None of my materials have gone into that much detail of requiring ATP to shuttle things and what not. However one thing to note is that the 2 NADH from glycolysis give 4 ATP and not 6. I don't remember the exact reasoning why and I'm we don't need to know that either

 

[sakthivs]

ok based on your source the reason why the 2 NADH from gylcolysis gives 4 ATP and not 6 is because they are assuming a ATP deduction from transferring NADH from cytosol to the mitochondria (which is minus 2 ATP).

man this is annoying....so you think we dont need to know this in huge detail? Should I just stick with a range of 36-38 ATP? But then what would the yield for bacteria be? bacteria doesn't have mitochondria so they don't have atp deductions so what would their yield be?

and are we just ignoring the ATP cost to move pyruvate into the mitochondria?

 

[Jordwin]

I would say know the fact that 2 ATP is lost when nadh is shuttled into the mitochondria. I haven't heard of pyruvate costing any ATP to cross, but on that one idk. I would say ignore that because all of the test prep questions have said 36 net ATP for one molecule of glucose.

 

[imrandom]

Yeah I can't find anything about the cost of transporting pyruvate into mitochondria. My sources (KBB and Cliffs) completely ignore it. They only take into account the NADH crossing the mitochondrial membrane.

Since bacteria is prokaryotic,it yeilds 38 ATP because the 2NADH from glycolysis don't have mitochondrial membranes to cross)

 

[sakthivs]

aight cool thanks guys i will just stick with the 36 atp for eukaroytic cells and 38 atp for prokaryotic.

 

[imrandom]

Yup no problem 👍
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