GLYCOLYSIS - ooo wee!

[busupshot83]

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I'm attempting to summarize glycolysis as thoroughly as possible, without memorzing the intermediates.

In glycolysis, which occurs in the cytoplasm, a 6-C glucose molecule is broken down into two 3-C pyruvate molecules, with a side product of 4 ATP molecules and 2 NADH molecules. There are two phases: the energy investment phase and the energy payoff phase. During the investment phase, the 6-C glucose is converted into two glyceraldehyde-2-phosphate (PGAL) molecules, a process which requires 2 ATP molecules. During the payoff phase, the two PGAL are converted into two pyruvate molecules, four ATP molecules, and two NADH molecules , a process which requires two NAD+ molecules, and four ADP molecules. In summary: 6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 4 ATP + 2 NADH.

Is the above information is correct? Will that information be sufficient enough to study for the DAT?

 

[fancymylotus]

I'm attempting to summarize glycolysis as thoroughly as possible, without memorzing the intermediates.

In glycolysis, which occurs in the cytoplasm, a 6-C glucose molecule is broken down into two 3-C pyruvate molecules, with a side product of 4 ATP molecules and 2 NADH molecules. There are two phases: the energy investment phase and the energy payoff phase. During the investment phase, the 6-C glucose is converted into two glyceraldehyde-2-phosphate (PGAL) molecules, a process which requires 2 ATP molecules. During the payoff phase, the two PGAL are converted into two pyruvate molecules, four ATP molecules, and two NADH molecules , a process which requires two NAD+ molecules, and four ADP molecules. In summary: 6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 4 ATP + 2 NADH.

Is the above information is correct? Will that information be sufficient enough to study for the DAT?

You might want to know that hexokinase is what turns glucose into g6p.Just a thought....not that it was on my DAT or anything😉

 

[Chga]

I'm attempting to summarize glycolysis as thoroughly as possible, without memorzing the intermediates.

In glycolysis, which occurs in the cytoplasm, a 6-C glucose molecule is broken down into two 3-C pyruvate molecules, with a side product of 4 ATP molecules and 2 NADH molecules. There are two phases: the energy investment phase and the energy payoff phase. During the investment phase, the 6-C glucose is converted into two glyceraldehyde-2-phosphate (PGAL) molecules, a process which requires 2 ATP molecules. During the payoff phase, the two PGAL are converted into two pyruvate molecules, four ATP molecules, and two NADH molecules , a process which requires two NAD+ molecules, and four ADP molecules. In summary: 6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 4 ATP + 2 NADH.

Is the above information is correct? Will that information be sufficient enough to study for the DAT?

I thought it was 6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 2 ATP + 2 NADH

 

[busupshot83]

thanks for the heads-up.

i'm confused about the dehydrogenase involved in glycolysis. can someone explain to me what i need to know about dehydrogenases in regards to glycolysis?

 

[busupshot83]

I thought it was 6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 2 ATP + 2 NADH

you might be referring to the kaplan book... what they mean is that there is a net gain of 2 ATP.

 

[Moni Ahmadian]

Another important detail of the glycolysis is that the rate determining step of this process is regulated by the enzyme phosphofructokinase (PFK) which turns out to consume an ATP molecule/F6P molecule. It attaches a phosphate group at the C 1 position using ATP as phosphate donor.

thanks for the heads-up.

i'm confused about the dehydrogenase involved in glycolysis. can someone explain to me what i need to know about dehydrogenases in regards to glycolysis?

 

[Streetwolf]

I thought it was 6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 2 ATP + 2 NADH

No he was right, it's 4. Just remember that there is a 2 ATP on the left side so the net result is 2 ATP produced (4 produced - 2 invested).

 

[Moni Ahmadian]

yes 4 produced and 2 consumed and it gives you a net ATP of 2.

No he was right, it's 4. Just remember that there is a 2 ATP on the left side so the net result is 2 ATP produced (4 produced - 2 invested).

 

[busupshot83]

I originally wrote:

6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 4 ATP + 2 NADH.

However, shouldn't there be some ADP molecules on the left side too?

6-C glucose + 2 ADP + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 4 ATP + 2 NADH.

I'm getting confusing... the 4 ATP molecules that are created during the payoff stage of glycolysis are generated from 4 ADP molecules (2 ADP created during investment stage, 2 more ADPs needed), right? So shouldn't they be in the equation?

 

[artsyme]

You might want to know that hexokinase is what turns glucose into g6p.Just a thought....not that it was on my DAT or anything😉

the DAT gets that specific? with the enzyme names? That's definitely NOT pointed out in kaplan. dammnit, I guess I have to whip out some biochemistry notes *fun* 😡

 

[Moni Ahmadian]

Dude those ADPs come from different cycles such as fatty acid processing and also from the cell internal activites. So don't worry about not having 4 ADPs there. 4ATPs are created but 2 ATPs are lost so you get a net 2ATP by each process of glycolysis

I originally wrote:

6-C glucose + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 4 ATP + 2 NADH.

However, shouldn't there be some ADP molecules on the left side too?

6-C glucose + 2 ADP + 2 ATP + 2 NAD+ --> two 3-C pyruvate + 4 ATP + 2 NADH.

I'm getting confusing... the 4 ATP molecules that are created during the payoff stage of glycolysis are generated from 4 ADP molecules (2 ADP created during investment stage, 2 more ADPs needed), right? So shouldn't they be in the equation?