Step I Goljan Neoplasia Lecture Question

[BMW M3]

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In his neoplasia lecture, goljan mentions something about "AUPA [sic!!!] tumors" i don't know what he is referring to... can anyone point in the in the right direction?

Thanks!

 

[osli]

APUD tumors... amine precursor uptake and decarboxylation.

 

[DwyaneWade]

APUD tumors... amine precursor uptake and decarboxylation.

Just a special name for those tumors which make peptides and are mostly of neuroendocrine origin?

 

[agranulocytosis]

I've heard them called APUDomas. From what I understand it's the blanket term for neuroendocrine tumors.

 

[DragonWell]

Please correct me if I'm wrong, but I believe they are also S-100 antigen positive and usually of neural crest origin, ie a melanoma.

 

[DwyaneWade]

Please correct me if I'm wrong, but I believe they are also S-100 antigen positive and usually of neural crest origin, ie a melanoma.

No that's right. Small cell carcinoma of the lung is also S-100 positive, as is pheo.

 

[docmd2010]

apud tumors are tumors of neural crest origin. they stain with s-100 because of the neurofilaments. another example is carcinoid tumors.

 

[osli]

Just a special name for those tumors which make peptides and are mostly of neuroendocrine origin?

Yup. APUD stuff is secretory, making the majority of the bodies' peptide hormones.

 

[BMW M3]

BRILLIANT!!! Thanks everyone.

here's a reference I found with all the tumors now that i know how to spell it:
http://training.seer.cancer.gov/module_cancer_disease/unit3_categories3_tumor_list_7.html