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Goljan Neoplasia Lecture Question

Discussion in 'Step I' started by BMW M3, May 13, 2008.

  1. BMW M3

    BMW M3 Senior Member
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    In his neoplasia lecture, goljan mentions something about "AUPA [sic!!!] tumors" i don't know what he is referring to... can anyone point in the in the right direction?

    Thanks!
     
  2. osli

    osli Senior Member
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    APUD tumors... amine precursor uptake and decarboxylation.
     
  3. DwyaneWade

    DwyaneWade Reiging *** Cynic
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    Just a special name for those tumors which make peptides and are mostly of neuroendocrine origin?
     
  4. agranulocytosis

    Physician 10+ Year Member

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    I've heard them called APUDomas. From what I understand it's the blanket term for neuroendocrine tumors.
     
  5. DragonWell

    Moderator Emeritus 10+ Year Member

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    Please correct me if I'm wrong, but I believe they are also S-100 antigen positive and usually of neural crest origin, ie a melanoma.
     
  6. DwyaneWade

    DwyaneWade Reiging *** Cynic
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    No that's right. Small cell carcinoma of the lung is also S-100 positive, as is pheo.
     
  7. docmd2010

    docmd2010 Senior Member
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    apud tumors are tumors of neural crest origin. they stain with s-100 because of the neurofilaments. another example is carcinoid tumors.
     
  8. osli

    osli Senior Member
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    Yup. APUD stuff is secretory, making the majority of the bodies' peptide hormones.
     
  9. BMW M3

    BMW M3 Senior Member
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