goljan rapid review page 31

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in goljan RR page 31,
2 e. Cross linking increases overall tensile strength of collagen and also elastic tissue.
-type 1 collagen in skin, bone, tendons has greatest tensile strength.

2 f. Cross linking increases with age which leads to decreased elasticity of skin, joints and blood vessels.

2 g. Decreased cross linking reduces tensile strength of collagen.

I am confused and my brain is fried.

 

[knuckles]

There is reduction in collagen fibers and solubility with degradation of elastic fibers.[8,9] Mucopolysaccharides, particularly hyaluronic acid, are reduced relative to collagen content.[10] Functionally, these changes result in decreased skin elasticity, extensibility, and turgor. Appendages including hair follicles, apocrine, and eccrine glands are decreased in number. Pacinian and Meissner's corpuscles, responsible for pressure and light touch sensation, are similarly decreased.


Less collagen, more crosslinking?

I also found this online somewhere:

Aging results in abnormal collagen and elastin metabolism. The result is increased collagen crosslinking which may explain decreased tensile strength, fragility, tissue strains and tears.
Elastin also undergoes increased cross linking and results in decreased elastic recoil in skin and other tissues.


Needless to say, I think the big picture is, that the crosslinking is disorderly in the elderly, and generally abnormal, relative to the smooth butts we all had exiting the womb.