Goljan RR pg 196 ?s about Ferritin/Transferrin

[lemonade90]

---

Members don't see this ad.

Questions about 3rd edition of RR Goljan Path

1-In Fig 11-7 (pg 196), what is the y axis supposed to be? I am thinking serum levels for transferrin (left column) and ferritin (right column).

2-What does the shading represent in Fig 11-7? I am thinking that it is saturation level for each protein. However what I don’t get is why in figures B-D, if the total ferritin changes, why the serum ferritin levels won’t go up or down as shown by an increase or decrease in the total right hand column size (i.e. similar to how the transferrin levels go up or down when more transferring is made by the liver)?

 

[Phlame217]

Questions about 3rd edition of RR Goljan Path

1-In Fig 11-7 (pg 196), what is the y axis supposed to be? I am thinking serum levels for transferrin (left column) and ferritin (right column).

2-What does the shading represent in Fig 11-7? I am thinking that it is saturation level for each protein. However what I don’t get is why in figures B-D, if the total ferritin changes, why the serum ferritin levels won’t go up or down as shown by an increase or decrease in the total right hand column size (i.e. similar to how the transferrin levels go up or down when more transferring is made by the liver)?

Y axis is Microgram/deciLiter concentration of the given item
ie: for the normal the TIBC is 300 and the saturation is 1/3 of that at 100.

Figures B-D the item labelled "Ferritin" are the ferritin stores in the macrophages that reside in bone marrow. They are usually constant in number, but able to carry various saturation levels of iron. Serum ferritin is the left most bar and bone marrow ferritin is the right most bar (so all these graphs represent the shift of iron in and out of bone marrow in various states of disease).

 

[lemonade90]

Thanks for the help.

With respect to your answer to my second question...why do you say that the first column is serum ferritin? Serum ferritin is supposed to be less than bone marrow ferritin stores.

 

[Phlame217]

Because that is what Goljan said in class two weeks ago.