Graduate Subject about " Leptin "

[LeVeterinair]

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Hello
I'm a vet student ! Well we study in french 🙄...mmm i'm looking for documents or references for my Graduation "Thèse" about the Leptin ! in french i didn't find lot of articles on the internet ! so i tryed to look in english ! but no important things too !
Well my study is about the Roles of Leptin in reproduction, as you know that the Leptin is late discovered (1994) and experiments still going on it...so it's hard little bit to find about ! except in "Les States" as we call it in france 🙄....PLZ can i have a hand ?

 

[Caninerepro]

What do you want/need. I am not a vet student until September, but I am finishing a Masters in reproductive endocrinology right now. What species do you need it in? Sorry, I speak passable spanish, but not french.

Maybe this will help. A lot of the stuff I have access to requires an account with a given journal, so you may need to get simmilar access.


Leptin, a 16kDa product of the adipose obese (ob) gene, has been shown to contribute to the regulation of energy metabolism, feeding behavior, and reproduction in several monogastric species, including humans. Recent reports have provided evidence that the leptin gene is functionally relevant in cattle and sheep, and may contribute to an array of important reproductive events, including puberty. Leptin gene expression and circulating leptin increase markedly during sexual maturation in heifers reaching puberty during late spring or early summer. In addition, serum leptin concentrations increased by over 30% from early winter to the summer solstice in mature cows, and also increased with significant changes in adiposity. However, only limited changes in circulating leptin have been observed during the estrous cycle. Short-term fasting of growing peripubertal heifers causes marked reductions in leptin gene expression and circulating leptin, concomitant with declines in LH pulse frequency, and serum concentrations of insulin and IGF-1. Although short-term fasting of mature cows in excellent body condition is without effects on LH pulse frequency, it has remarkably similar metabolic effects to those observed in heifers. Moreover, ICV administration of recombinant oleptin resulted in a marked hypersecretion of LH in fasted cows, and in vitro studies using both hypothalamic and anterior pituitary explants have provided evidence that this effect is at the pituitary level. Paradoxically, ICV administration of oleptin normalized circulating insulin in fasted cows but hleptin was without effect on insulin in estradiol-implanted wethers. Collectively, work in cattle and sheep indicates that leptin can modulate both the hypothalamic-pituitary axis and endocrine pancreas under defined nutritional conditions. Additional work to more fully characterize these roles is clearly warranted and could lead to the development of novel strategies for modifying reproductive potential in food-producing species.

Leptin and its role in the central regulation of reproduction in cattle

Domest Anim Endocrinol. July 2002;23(1-2):339-49. 58 Refs

G L Williams1, M Amstalden, M R Garcia, R L Stanko, S E Nizielski, C D Morrison, D H Keisler
1 Animal Reproduction Laboratory, Texas A&M University Agricultural Research Station, Beeville 78102, USA. [email protected]

Abstract

 

[LeVeterinair]

What do you want/need. I am not a vet student until September, but I am finishing a Masters in reproductive endocrinology right now. What species do you need it in? Sorry, I speak passable spanish, but not french.

Maybe this will help. A lot of the stuff I have access to requires an account with a given journal, so you may need to get simmilar access.


Leptin, a 16kDa product of the adipose obese (ob) gene, has been shown to contribute to the regulation of energy metabolism, feeding behavior, and reproduction in several monogastric species, including humans. Recent reports have provided evidence that the leptin gene is functionally relevant in cattle and sheep, and may contribute to an array of important reproductive events, including puberty. Leptin gene expression and circulating leptin increase markedly during sexual maturation in heifers reaching puberty during late spring or early summer. In addition, serum leptin concentrations increased by over 30% from early winter to the summer solstice in mature cows, and also increased with significant changes in adiposity. However, only limited changes in circulating leptin have been observed during the estrous cycle. Short-term fasting of growing peripubertal heifers causes marked reductions in leptin gene expression and circulating leptin, concomitant with declines in LH pulse frequency, and serum concentrations of insulin and IGF-1. Although short-term fasting of mature cows in excellent body condition is without effects on LH pulse frequency, it has remarkably similar metabolic effects to those observed in heifers. Moreover, ICV administration of recombinant oleptin resulted in a marked hypersecretion of LH in fasted cows, and in vitro studies using both hypothalamic and anterior pituitary explants have provided evidence that this effect is at the pituitary level. Paradoxically, ICV administration of oleptin normalized circulating insulin in fasted cows but hleptin was without effect on insulin in estradiol-implanted wethers. Collectively, work in cattle and sheep indicates that leptin can modulate both the hypothalamic-pituitary axis and endocrine pancreas under defined nutritional conditions. Additional work to more fully characterize these roles is clearly warranted and could lead to the development of novel strategies for modifying reproductive potential in food-producing species.

Leptin and its role in the central regulation of reproduction in cattle

Domest Anim Endocrinol. July 2002;23(1-2):339-49. 58 Refs

G L Williams1, M Amstalden, M R Garcia, R L Stanko, S E Nizielski, C D Morrison, D H Keisler
1 Animal Reproduction Laboratory, Texas A&M University Agricultural Research Station, Beeville 78102, USA. [email protected]

Abstract

Thank you Dr. that's realy nice from you. Well i need some studies on Leptin especialy in Canine & Feline, and about reproduction for Ruminants than the Problematica of Leptin..Well i'm sorry little bit because i'm building "Le Plan" and i'v to finish all the work before may2010, so now i'm in collecting informations, and some bibliographic research, at the same time i'm contacting my "Encadreur" (it means Framer by direct translation) She's a Professor in Reproduction...
By the way, can you tell me please from where can i get the journal, i think it's a very important ref. thank you again.merci 🙂
I found some interesting document till now about Biochemistry of Leptin (by Indian students), and i'v some french articles Leptin for chiken 'La Leptine chez le poulet'.And here's another document : View attachment Bsiliart.pdf

Some pics:

 

[Caninerepro]

Plasma leptin concentration in dogs: effects of body condition score, age, gender and breeds

Res Vet Sci. February 2007;82(1):11-5.
K Ishioka1, K Hosoya, H Kitagawa, H Shibata, T Honjoh, K Kimura, K Kimura, M Saito
1 Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1, Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan. [email protected]

Abstract

Leptin is a cytokine produced by adipocytes, and plays a key role in the regulation of energy balance. In the present study, we measured plasma leptin concentrations of 166 normal and obese dogs visiting veterinary practices, and clarified the influence of age, gender and breed on plasma leptin levels in dogs. Leptin levels were higher in the dogs with higher body condition scores. There was no noticeable influence of age, gender and breed, but those in optimal puppies and obese Miniature Dachshund tended to be lower than those in corresponding groups. We conclude that plasma leptin is a reliable marker of adiposity in dogs regardless of age, gender and breed variations, and thereby useful as a blood biochemistry test for health examinations and treatment of obesity.

Leptin: pharmacological aspects in gynecology

Clin Exp Obstet Gynecol. 2006;33(2):113-6.
M Sorace1, L Tripodi, A Tripodi, D Groppetti, F Cremonesi
1 Department of Gynecology and Obstetrics, AZ Hospital of Reggio Calabria, Italy.

Abstract

Hematic levels of leptin vary in relation to numerous metabolic factors and are able to interact in perfect synchrony with the hormones involved in the hypothalamus-pituitary-ovarian axis during the various phases of the reproductive cycle. In general it is maintained that the complex and multiple action mechanisms of leptin need to be clarified by further in-depth research studies. It is likely that valid pharmacological applications of leptin will be found for human use although it is too premature to talk about concrete pharmacological answers and to formulate the relative complete technical protocols. In medicine the therapeutic use of leptin for humans has been reported in only a few cases. In fact human recombinant leptin has already been administered in gynecology for hypothalamic amenorrhea with precise protocols. In addition, very recent studies have provided the basis for new strategies to be developed concerning the use of leptin to fight multiple sclerosis. At present there are considerable technical and economic problems in the production of leptin on a large scale. Most likely these problems will be overcome in the foreseeable future, and will involve new techniques related to genetics, cellular reprograming, and stem cells. In fact, new pharmacogenetic research has provided encouraging results for the production in industrial quantities of a more effective and fail-proof leptin. Even considering that norms have not yet been proposed for pharmacological interventions with leptin for use directly on humans, in our work we have studied by immunohistochemistry methods the distribution of leptin and its receptor (Ob-R) in the ovaries of the female dog as a biological model, in the pre- and postpubertal phases and in other phases of the ovarian cycle. Given the hypothesis that the information obtained from immunohistochemical localization of the hormone and its receptor in various ovarian structures is transferable to humans, it could be useful to define therapeutic protocols based on the effective role of leptin and its receptor in folliculogenesis.

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These are the first two abstracts that I came up with off of the VIN. The Journals are listed with each abstract. I would presume that your institution can get you access to these through their library system, or your advisor can.